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Telomeres, p21 and the cancer-aging hypothesis

Nature Genetics volume 39, pages 11–12 (2007)Cite this article

Telomere dysfunction suppresses cancer through the p53 tumor suppressor pathway but also contributes to aging. A new study suggests that these effects of dysfunctional telomeres may be separable, such that aging—but not cancer suppression—depends on the p21 cell cycle inhibitor.

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Figure 1: The role of p21 in the p53 response.

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Authors and Affiliations

  1. Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, 27599, North Carolina, USA

    Jessica F Bell & Norman E Sharpless

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  1. Jessica F Bell
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  2. Norman E Sharpless
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Bell, J., Sharpless, N. Telomeres, p21 and the cancer-aging hypothesis. Nat Genet 39, 11–12 (2007). https://doi.org/10.1038/ng0107-11

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