Replication initiation factors are essential for cell proliferation and thus are not expected to be disrupted in cancers. Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas.
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Katie Ris
References
Shima, N. et al. Nat. Genet. 39, 93–98 (2007).
Yoshida, K., Kuo, F., George, E.L., Sharpe, A.H. & Dutta, A. Mol. Cell. Biol. 21, 4598–4603 (2001).
Pinto, S. et al. Neuron 23, 45–54 (1999).
Woodward, A.M. et al. J. Cell Biol. 173, 673–683 (2006).
Blow, J.J. & Dutta, A. Nat. Rev. Mol. Cell Biol. 6, 476–486 (2005).
Machida, Y.J., Hamlin, J.L. & Dutta, A. Cell 123, 13–24 (2005).
Arentson, E. et al. Oncogene 21, 1150–1158 (2002).
Karakaidos, P. et al. Am. J. Pathol. 165, 1351–1365 (2004).
Shreeram, S., Sparks, A., Lane, D.P. & Blow, J.J. Oncogene 21, 6624–6632 (2002).
Machida, Y.J., Teer, J.K. & Dutta, A. J. Biol. Chem. 280, 27624–27630 (2005).
Ekholm-Reed, S. et al. J. Cell Biol. 165, 789–800 (2004).
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Dutta, A. Chaotic license for genetic instability and cancer. Nat Genet 39, 10–11 (2007). https://doi.org/10.1038/ng0107-10
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DOI: https://doi.org/10.1038/ng0107-10
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