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Chaotic license for genetic instability and cancer

Nature Genetics volume 39, pages 1011 (2007) | Download Citation

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Replication initiation factors are essential for cell proliferation and thus are not expected to be disrupted in cancers. Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas.

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Author information

Affiliations

  1. Anindya Dutta is at the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA. ad8q@virginia.edu

    • Anindya Dutta

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https://doi.org/10.1038/ng0107-10

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