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Amyloid double trouble

A new study shows that some cases of early-onset Alzheimer disease result from duplications of the APP locus, which encodes the amyloid β precursor protein. This finding fulfills a 20-year-old prediction that genetic variability in APP expression could lead to disease and provides further, perhaps definitive, evidence for the amyloid hypothesis of the disorder.

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Figure 1: Genetic factors influencing Aβ42 production and Alzheimer disease onset.


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Hardy, J. Amyloid double trouble. Nat Genet 38, 11–12 (2006).

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