In search of the limits of evolution

Negative trade-offs are thought to be a pervasive phenomenon and to inhibit evolution at all levels. New evidence shows that at the molecular level, there may be no trade-offs preventing the emergence of an enzyme with multiple functions.

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Figure 1: A three-dimensional representation of the concept of fitness surfaces in genotype space.

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Kondrashov, F. In search of the limits of evolution. Nat Genet 37, 9–10 (2005). https://doi.org/10.1038/ng0105-9

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