The methylome—a neologism that describes the complete set of DNA methylation modifications of a cell—has its own life cycle, and alterations in the methylome may be linked to aging and cancer, as well as polymorphic variation in populations. A study of the methylome in embryonic fibroblasts further underscores the potent effect of p53 expression.
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Feinberg, A. Methylation meets genomics. Nat Genet 27, 9–10 (2001). https://doi.org/10.1038/83825
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DOI: https://doi.org/10.1038/83825
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