A peptide needle in a signaling haystack

Expressing random peptides within cells has been hampered by technical problems, and so a simple method to express random free peptide libraries within mammalian cells comes as a welcome advance. It offers a powerful new way to approach the analysis of complex signal transduction cascades, as is illustrated in dissecting the emergence of tumor cell resistance to the chemotherapeutic drug taxol.

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Roepe, P. A peptide needle in a signaling haystack. Nat Genet 27, 6–8 (2001) doi:10.1038/83775

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