Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cytoskeletal catastrophe causes brain degeneration

Nature Genetics volume 27, pages 10–11 (2001)Cite this article

A number of spontaneous mutations in GFAP, encoding an astrocyte-specific intermediate filament protein, causes a neurodegenerative disease. It seems probable that these mutations effect gain of function of the GFAP filament and thereby have an impact on the cytoskeletal architecture and interactions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Messing, A. et al. Nature Genet. 27, 117– 120 (2001).

    Article  Google Scholar 

  2. Quinlan, R.A., Hutchison, C.J. & Lane, E.B. Protein Profiles 2, 801– 952 (1995).

    CAS  Google Scholar 

  3. Irvine, A.D. & McLean, W.H.I. Br. J. Dermatol. 140, 815–828 (1999).

    Article  CAS  Google Scholar 

  4. Conley, Y.P. et al. Am. J. Hum. Genet. 66, 1426– 1431 (2000).

    Article  CAS  Google Scholar 

  5. Raffaele Di Barletta, M. et al. Am. J. Hum. Genet. 66, 1407– 1412 (2000).

    Article  CAS  Google Scholar 

  6. Perng, M.D. et al. J. Cell Sci. 112, 2099– 2112 (1999).

    CAS  PubMed  Google Scholar 

  7. Mann, E., McDermott, M.J., Goldman, J., Chiesa, R. & Spector, A. FEBS Lett. 294, 133–136 (1991).

    Article  CAS  Google Scholar 

  8. Tomokane, N., Iwaki, T., Tateishi, J., Iwaki, A. & Goldman, J.E. Am. J. Pathol. 138, 875– 885 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Shibuki, K. et al. Neuron 16, 587–599 (1996).

    Article  CAS  Google Scholar 

  10. Pekny, M. et al. EMBO J. 14, 1590–1598 (1995).

    Article  CAS  Google Scholar 

  11. Pekny, M. et al. J. Cell Biol. 145, 503– 514 (1999).

    Article  CAS  Google Scholar 

  12. Messing, A. et al. Am. J. Pathol. 152, 391– 398 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Li, D. et al. Circulation 100, 461–464 (1999).

    Article  CAS  Google Scholar 

  14. Cary, R.B. & Klymkowsky, M.W. Development 121 , 1041–1052 (1995).

    CAS  PubMed  Google Scholar 

  15. Eliasson, C. et al. J. Biol. Chem. 274, 23996– 24006 (1999).

    Article  CAS  Google Scholar 

  16. Herrmann, H. & Aebi, U. Curr. Opin. Cell Biol. 12, 79–90 (2000).

    Article  CAS  Google Scholar 

  17. Perng M.D. et al. J. Biol. Chem. 274, 33235– 33243 (1999).

    Article  CAS  Google Scholar 

  18. Fairley, E.A.L., Kendrick-Jones, J. & Ellis, J.A. J. Cell Sci. 112, 2571– 2582 (1999).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences, South Road, Durham, DH1 3LE, UK

    Roy Quinlan

Authors
  1. Roy Quinlan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Quinlan, R. Cytoskeletal catastrophe causes brain degeneration. Nat Genet 27, 10–11 (2001). https://doi.org/10.1038/83657

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/83657

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing