Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

Nature Genetics volume 24, pages 15–16 (2000)Cite this article

Abstract

Fanconi anaemia (FA) is a chromosomal instability syndrome with autosomal recessive inheritance. We have identified the gene mutated in Fanconi anaemia group F patients by complementation cloning. FANCF has no introns and encodes a polypeptide with homology to the prokaryotic RNA binding protein ROM.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Complementation of MMC hypersensitivity and absence of full-length FANCF protein in FA-F lymphoblastoid cell lines.
Figure 2: FANCF protein has homology to the prokaryotic RNA-binding protein ROM.

Similar content being viewed by others

References

  1. Auerbach, A.D., Buchwald, M. & Joenje, H. The Genetic Basis of Human Cancer (eds Vogelstein, B. & Kinzler, K.W.) 317–332 (McGraw-Hill, New York, 1998).

    Google Scholar 

  2. Joenje, H. et al. Am. J. Hum. Genet. 61, 940– 944 (1997).

    Article  CAS  Google Scholar 

  3. Lo Ten Foe, J.R. et al. Nature Genet. 14, 320– 323 (1996).

    Article  CAS  Google Scholar 

  4. The Fanconi anemia/breast cancer consortium. Nature Genet. 14, 324–328 (1996).

  5. Strathdee, C.A., Gavish, H., Shannon, W.R. & Buchwald, M. Nature 356, 763–767 ( 1992).

    Article  CAS  Google Scholar 

  6. De Winter, J.P. et al. Nature Genet. 20, 281– 283 (1998).

    Article  CAS  Google Scholar 

  7. Whitney, M. et al. Nature Genet. 11, 341– 343 (1995).

    Article  CAS  Google Scholar 

  8. Waisfisz, Q. et al. Am. J. Hum. Genet. 64, 1400– 1405 (1999).

    Article  CAS  Google Scholar 

  9. Henikoff, S. & Henikoff, J.G. Genomics 19, 97–107 (1994).

    Article  CAS  Google Scholar 

  10. Tomizawa, J.I. & Som, T. Cell 38 , 871–878 (1984).

    Article  CAS  Google Scholar 

  11. Predki, P.F., Nayak, L.M., Gottlieb, M.B.C. & Regan, L. Cell 80, 41–50 ( 1995).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the FA families for participating; S. Ball, M. van Weel-Sipman and C.E.M. de Die-Smulders for referring patients; and N. Cool, I. Gruijs, N.V. Morgan, A.B. Oostra and J. Steltenpool for contributing to the complementation studies. Financial support was from the Dutch Cancer Society (VU-97-1565), the Fanconi Anemia Research Fund, Inc., the FA patient support organizations in Europe, the Commission of the European Union (Contracts PL931562 and BMH4-98-3784), the National Institutes of Health (HL56045, HL50301) and the Medical Research Council of Canada.

Author information

Authors and Affiliations

  1. Department of Clinical Genetics and Human Genetics, Free University, Amsterdam, The Netherlands

    Johan P. de Winter, Martin A. Rooimans, Laura van der Weel, Carola G.M. van Berkel, Quinten Waisfisz, Jan C. Pronk, Fré Arwert & Hans Joenje

  2. Program in Genetics and Genomic Biology, The Hospital for Sick Children,

    Noa Alon, Lucine Bosnoyan-Collins & Manuel Buchwald

  3. Department of Molecular and Medical Genetics, The University of Toronto, Toronto, Ontario, Canada

    Noa Alon, Lucine Bosnoyan-Collins & Manuel Buchwald

  4. Department of Pathology, Free University Hospital, Amsterdam, The Netherlands

    Jan de Groot & Rik J. Scheper

  5. Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, Oregon, USA

    Yu Zhi & Maureen E. Hoatlin

  6. Division of Medical and Molecular Genetics, GKT School of Medicine, Guy's Hospital, London, UK

    Christopher G. Mathew

Authors
  1. Johan P. de Winter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin A. Rooimans
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laura van der Weel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Carola G.M. van Berkel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Noa Alon
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lucine Bosnoyan-Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jan de Groot
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yu Zhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Quinten Waisfisz
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jan C. Pronk
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Fré Arwert
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Christopher G. Mathew
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Rik J. Scheper
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Maureen E. Hoatlin
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Manuel Buchwald
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Hans Joenje
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hans Joenje.

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Winter, J., Rooimans, M., van der Weel, L. et al. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. Nat Genet 24, 15–16 (2000). https://doi.org/10.1038/71626

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/71626

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing