GATA2 mutations lead to MDS and AML

Several new studies report mutations in the gene GATA2 in three different familial syndromes characterized by predisposition to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Before the onset of MDS and AML, patients with similar GATA2 mutations had distinct hematological abnormalities.

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Figure 1: GATA2 mutations.

References

  1. 1

    Owen, C., Barnett, M. & Fitzgibbon, J. Br. J. Haematol. 140, 123–132 (2008).

  2. 2

    Hahn, C.N. et al. Nat. Genet. 43, 929–931 (2011).

  3. 3

    Ostergaard, P. et al. Nat. Genet. 43, 1012–1017 (2011).

  4. 4

    Mansour, S. et al. Am. J. Med. Genet. A. 152A, 2287–2296 (2010).

  5. 5

    Hsu, A.P. et al. Blood published online, doi:10.1182/blood-2011-05-356352 (13 June 2011).

  6. 6

    Dickinson, R.E. et al. Blood published online, doi:10.1182/blood-2011-06-360313 (15 July 2011).

  7. 7

    Vinh, D.C. et al. Blood 115, 1519–1529 (2010).

  8. 8

    Calvo, K.R. et al. Haematol. 96, 1221–1225 (2011).

  9. 9

    Bigley, V. et al. J. Exp. Med. 208, 227–234 (2011).

  10. 10

    Rodrigues, N.P. et al. Blood 112, 4862–4873 (2008).

  11. 11

    Zhang, S.J. et al. Proc. Natl. Acad. Sci. USA 105, 2076–2081 (2008).

  12. 12

    Zhang, S.J., Shi, J.Y. & Li, J.Y. Leuk. Res. 33, 1141–1143 (2009).

  13. 13

    Vicente, C., Conchillo, A., Garcia-Sanchez, M.A. & Odero, M.D. Crit. Rev. Oncol. Hematol. published online, doi:10.1016/jcritrevonc.2011.04.007 (24 May 2011).

  14. 14

    Wechsler, J. et al. Nat. Genet. 32, 148–152 (2002).

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Correspondence to P. Paul Liu.

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Hyde, R., Liu, P. GATA2 mutations lead to MDS and AML. Nat Genet 43, 926–927 (2011). https://doi.org/10.1038/ng.949

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