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A20 edits ubiquitin and autoimmune paradigms

Nature Genetics volume 43, pages 822823 (2011) | Download Citation

Complex autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis and inflammatory bowel disease have different pathological presentations but have overlapping genetic susceptibility variants. A new study using mice lacking Tnfaip3, whose ortholog is linked to autoimmune disease in humans, leads to insights in the role of one molecular driver of varied clinical symptomatology in disparate autoimmune disorders.

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Author information

Affiliations

  1. Flavius Martin is in the Department of Immunology, Genentech, South San Francisco, California, USA.

    • Flavius Martin
  2. Vishva M. Dixit is in the Department of Physiological Chemistry, Genentech, South San Francisco, California, USA.

    • Vishva M Dixit

Authors

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  2. Search for Vishva M Dixit in:

Competing interests

F.M. and V.M.D. are employees of Genentech, a member of the Roche group.

Corresponding authors

Correspondence to Flavius Martin or Vishva M Dixit.

About this article

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DOI

https://doi.org/10.1038/ng.916

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