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Lyp breakdown and autoimmunity

Nature Genetics volume 43, pages 821822 (2011) | Download Citation

A new study shows that the PTPN22 coding variant associated with autoimmunity is a loss-of-function allele that causes the protein tyrosine phosphatase encoded by PTPN22 to undergo accelerated degradation, resulting in enhanced signaling in several immune cell types.

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Author information

Affiliations

  1. Timothy W. Behrens is in the Division of Immunology, Tissue Growth & Repair, Biomarker Discovery and Human Genetics, Genentech, South San Francisco, California, USA.

    • Timothy W Behrens

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Competing interests

T.W.B. is a full-time employee of Genentech.

Corresponding author

Correspondence to Timothy W Behrens.

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DOI

https://doi.org/10.1038/ng.914

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