Brief Communication | Published:

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

Nature Genetics volume 40, pages 281283 (2008) | Download Citation

Abstract

We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 × 10−13 and 7.7 × 10−9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

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Acknowledgements

We thank the individuals who participated in the study and whose contribution made this work possible. This project was funded in part by contract number 018827 (Polygene) from the 6th Framework Program of the EU to deCODE genetics, T.R. and L.A.K. The study was supported in part by National Cancer Institute CA105055, CA106523 and CA95052 to J.X., CA112517 and CA58236 to W.B.I., CA86323 to A.W.P., and Department of Defense grant PC051264 to J.X., and in part by a V Foundation award and US Department of Veterans Affairs grants to J.R.S. The principal investigators and corresponding authors for the respective replication study populations are L.A.K. (The Netherlands), J.I.M. (Spain), H.G. (Sweden), W.B.I. (Baltimore), W.J.C. (Chicago), J.R.S. (Nashville) and S.N.T. (Rochester).

Author information

Author notes

    • Julius Gudmundsson
    •  & Patrick Sulem

    These authors contributed equally to this work.

Affiliations

  1. deCODE genetics, 101 Reykjavik, Iceland.

    • Julius Gudmundsson
    • , Patrick Sulem
    • , Thorunn Rafnar
    • , Jon T Bergthorsson
    • , Andrei Manolescu
    • , Daniel Gudbjartsson
    • , Asgeir Sigurdsson
    • , Thorarinn Blondal
    • , Margret Jakobsdottir
    • , Simon N Stacey
    • , Jelena Kostic
    • , Kari T Kristinsson
    • , Birgitta Birgisdottir
    • , Shyamali Ghosh
    • , Droplaug N Magnusdottir
    • , Steinunn Thorlacius
    • , Gudmar Thorleifsson
    • , Michael L Frigge
    • , Kristleifur Kristjansson
    • , Jeffrey R Gulcher
    • , Unnur Thorsteinsdottir
    • , Augustine Kong
    •  & Kari Stefansson
  2. Department of Pathology, Landspitali-University Hospital, 101 Reykjavik, Iceland.

    • Bjarni A Agnarsson
    • , Kristrun R Benediktsdottir
    •  & Rosa B Barkardottir
  3. Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

    • S Lilly Zheng
    • , Jielin Sun
    • , Bao-Li Chang
    •  & Jianfeng Xu
  4. Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

    • J Bradford Elmore
    • , Joan P Breyer
    • , Kate M McReynolds
    • , Kevin M Bradley
    • , Brian L Yaspan
    •  & Jeffrey R Smith
  5. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, S-17177 Stockholm, Sweden.

    • Fredrik Wiklund
    • , Sara Lindström
    • , Hans-Olov Adami
    •  & Henrik Gronberg
  6. Department of Urology, Umea University Hospital, S-90185 Umea, Sweden.

    • Par Stattin
  7. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

    • Hans-Olov Adami
  8. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

    • Shannon K McDonnell
    • , Daniel J Schaid
    • , James R Cerhan
    •  & Jennifer L St Sauver
  9. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

    • Julie M Cunningham
    • , Liang Wang
    •  & Stephen N Thibodeau
  10. Brady Urological Institute, Johns Hopkins Medical Institution, Baltimore, Maryland 21209, USA.

    • Sara D Isaacs
    • , Kathleen E Wiley
    • , Alan W Partin
    • , Patrick C Walsh
    •  & William B Isaacs
  11. Division of Radiation Oncology, Quiron Hospital, 50009 Zaragoza, Spain.

    • Sonia Polo
  12. Division of Medical Oncology, Lozano Blesa University Hospital, University of Zaragoza, 50009 Zaragoza, Spain.

    • Manuel Ruiz-Echarri
    •  & Jose I Mayordomo
  13. Division of Radiation Oncology, Lozano Blesa University Hospital, University of Zaragoza, 50009 Zaragoza, Spain.

    • Sebastian Navarrete
    •  & Fernando Fuertes
  14. Health Sciences Institute, 50009 Zaragoza, Spain.

    • Berta Saez
    • , Javier Godino
    •  & Jose I Mayordomo
  15. Nanotechnology Institute of Aragon, 50009 Zaragoza, Spain.

    • Berta Saez
    •  & Jose I Mayordomo
  16. Department of Urology, Rijnstate Hospital, NL-6800 TA Arnhem, The Netherlands.

    • Philip C Weijerman
  17. Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

    • Dorine W Swinkels
  18. Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands.

    • Katja K Aben
    •  & Lambertus A Kiemeney
  19. Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

    • Katja K Aben
    •  & Lambertus A Kiemeney
  20. Department of Urology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

    • J Alfred Witjes
    •  & Lambertus A Kiemeney
  21. Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.

    • Brian K Suarez
  22. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

    • Brian T Helfand
    •  & William J Catalona
  23. Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.

    • Carole Ober
  24. Department of Urology, Landspitali-University Hospital, 101 Reykjavik, Iceland.

    • Eirikur Jonsson
    •  & Gudmundur V Einarsson
  25. Medical Research Service, VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, USA.

    • Jeffrey R Smith

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Competing interests

The authors from deCODE genetics are share holders in deCODE genetics Inc.

Corresponding authors

Correspondence to Julius Gudmundsson or Kari Stefansson.

Supplementary information

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    Supplementary Text and Figures

    Supplementary Methods, Supplementary Tables 1–5

About this article

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DOI

https://doi.org/10.1038/ng.89

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