Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 × 10−13 and 7.7 × 10−9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
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Acknowledgements
We thank the individuals who participated in the study and whose contribution made this work possible. This project was funded in part by contract number 018827 (Polygene) from the 6th Framework Program of the EU to deCODE genetics, T.R. and L.A.K. The study was supported in part by National Cancer Institute CA105055, CA106523 and CA95052 to J.X., CA112517 and CA58236 to W.B.I., CA86323 to A.W.P., and Department of Defense grant PC051264 to J.X., and in part by a V Foundation award and US Department of Veterans Affairs grants to J.R.S. The principal investigators and corresponding authors for the respective replication study populations are L.A.K. (The Netherlands), J.I.M. (Spain), H.G. (Sweden), W.B.I. (Baltimore), W.J.C. (Chicago), J.R.S. (Nashville) and S.N.T. (Rochester).
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The authors from deCODE genetics are share holders in deCODE genetics Inc.
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Gudmundsson, J., Sulem, P., Rafnar, T. et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet 40, 281–283 (2008). https://doi.org/10.1038/ng.89
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DOI: https://doi.org/10.1038/ng.89
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