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Mapping higher order structure of chromatin domains

Nature Genetics volume 43, pages 615616 (2011) | Download Citation

Large-scale mapping of chromatin state and transcription factor binding have uncovered many broad chromatin domains along linear genomic DNA, but it is unclear how these functional domains are organized in three-dimensional nuclear space. A new study now shows that many domains exist as loops connected by CCTC-binding factor (CTCF), providing new insights into the higher-order structure of chromatin organization in the nucleus.

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Author information

Affiliations

  1. Celso A. Espinoza and Bing Ren are at the Ludwig Institute for Cancer Research at the University of California, San Diego, La Jolla, California, USA.

    • Celso A Espinoza
    •  & Bing Ren

Authors

  1. Search for Celso A Espinoza in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Bing Ren.

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DOI

https://doi.org/10.1038/ng.869

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