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Regulating mRNA complexity in the mammalian brain

Nature Genetics volume 43, pages 618619 (2011) | Download Citation

Although there are only 22,000 human genes, most express multiple mRNA isoforms through alternative splicing and selection of alternative 5′ and 3′ ends. A new study identifies the role of alternative splicing in maintaining neuronal excitability in the adult mouse brain.

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References

  1. 1.

    , & Genes Dev. 23, 1379–1386 (2009).

  2. 2.

    & Trends Genet. 27, 89–97 (2011).

  3. 3.

    et al. Nat. Genet. 43, 706–711 (2011).

  4. 4.

    Cell. Mol. Life Sci. 66, 3895–3907 (2009).

  5. 5.

    & Genes Dev. 8, 1561–1574 (1994).

  6. 6.

    , & Genes Dev. 23, 2284–2293 (2009).

  7. 7.

    et al. Genes Dev. 22, 2550–2563 (2008).

  8. 8.

    et al. Science 329, 439–443 (2010).

  9. 9.

    et al. PLoS Genet. 4, e1000278 (2008).

  10. 10.

    et al. Genes Dev. 24, 1634–1644 (2010).

  11. 11.

    , , , & Cell 144, 16–26 (2011).

  12. 12.

    et al. RNA 13, 563–572 (2007).

  13. 13.

    et al. Proc. Natl. Acad. Sci. USA 105, 20333–20338 (2008).

  14. 14.

    , , & Neuron 66, 848–858 (2010).

  15. 15.

    et al. Proc. Natl. Acad. Sci. USA 106, 3513–3518 (2009).

  16. 16.

    et al. Nature published online, doi:10.1038/nature10110 (25 May 2011).

Download references

Author information

Affiliations

  1. Thomas A. Cooper is at the Baylor College of Medicine, Houston, Texas, USA.

    • Thomas A Cooper

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Thomas A Cooper.

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DOI

https://doi.org/10.1038/ng.867

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