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SOX2 and CHD7 cooperatively regulate human disease genes

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A new study reveals that the HMG-box transcription factor SOX2 coupled with the chromatin remodeling helicase CHD7 cooperatively regulate target genes that are essential during neural stem cell development. Notably, this complex controls the expression of several disease-associated genes, suggesting a possible mechanistic connection between five seemingly unrelated human genetic disorders.

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Figure 1: The SOX2-CHD7 helicase network and human disease.

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Correspondence to Michael G Rosenfeld.

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The authors declare no competing financial interests.

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Puc, J., Rosenfeld, M. SOX2 and CHD7 cooperatively regulate human disease genes. Nat Genet 43, 505–506 (2011). https://doi.org/10.1038/ng.843

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