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Conducting the metabolic syndrome orchestra

Genetic and gene expression studies have suggested an important role for KLF14 in metabolic disease. A new study now identifies a network of genes whose expression is associated with KLF14 variation in trans, providing a framework for understanding how KLF14 influences disease risk.

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Figure 1: Identification of a KLF14-associated trans regulatory network.

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Correspondence to Aldons J Lusis.

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Civelek, M., Lusis, A. Conducting the metabolic syndrome orchestra. Nat Genet 43, 506–508 (2011). https://doi.org/10.1038/ng.842

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