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Genome-wide association study identifies a common variant associated with risk of endometrial cancer

Nature Genetics volume 43, pages 451–454 (2011)Cite this article

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Abstract

Endometrial cancer is the most common malignancy of the female genital tract in developed countries. To identify genetic variants associated with endometrial cancer risk, we performed a genome-wide association study involving 1,265 individuals with endometrial cancer (cases) from Australia and the UK and 5,190 controls from the Wellcome Trust Case Control Consortium. We compared genotype frequencies in cases and controls for 519,655 SNPs. Forty seven SNPs that showed evidence of association with endometrial cancer in stage 1 were genotyped in 3,957 additional cases and 6,886 controls. We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10−10) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.

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Figure 1: Forest plot showing the association between rs4430796 and endometrial cancer for each component of the study.

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Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC; ID 552402), the Wellcome Trust and by Cancer Research UK grants C1287/A10118, C490/A1021, C8197/A10865 and C8197/A10123. A.B.S. and P.M.W. are NHMRC Senior Research Fellows, and G.M. is an NHMRC Senior Principle Research Fellow. T.O. is supported by an Australian Postgraduate Award, an Institute of Health and Biomedical Innovation PhD Top-Up and a Smart State PhD Award. L.C.W. is a John Gavin Postdoctoral Fellow (Genesis Oncology Trust, New Zealand). D.F.E. is a Principal Research Fellow of Cancer Research UK. A.M.D. is supported by the Joseph Mitchell Trust. I.T. is supported by Cancer Research UK and the Oxford Comprehensive Biomedical Research Centre. P.A.F. was partly funded by the Dr. Mildred Scheel Stiftung of the Deutsche Krebshilfe (German Cancer Aid).

This study makes use of data generated by the Wellcome Trust Case Control Consortium (WTCCC) 2. A full list of the investigators who contributed to the generation of the data is available from the WTCCC website. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. Funding for this project was provided by the Wellcome Trust under award 085475.

We thank the study participants and collaborators and the research teams involved in the design and implementation of the individual studies included (see Supplementary Note for full list of collaborators and specific acknowledgments). Australian National Endometrial Cancer Study (ANECS) recruitment was supported by project grants from the National Health and Medical Research Council of Australia (ID#339435), The Cancer Council Queensland (ID#4196615) and Cancer Council Tasmania (ID#403031 and ID#457636). The Bavarian Endometrial Cancer Study (BECS) was partly funded by the Erlanger Leistungsbezogene Anschubfinanzierung und Nachwuchsförderung Fond (ELAN fund) of the University of Erlangen. The Leuven Endometrium Study (LES) was supported by the Verelst Foundation for endometrial cancer. Molecular Markers in Treatment of Endometrial Cancer (MoMaTEC) received financial support from a Helse Vest Grant, the University of Bergen, Melzer Foundation, the Norwegian Cancer Society (Harald Andersens legat), the Research Council of Norway and Haukeland University Hospital. The Newcastle Endometrial Cancer Study (NECS) acknowledges contributions from the University of Newcastle, the National Broadcasting Network (NBN) Children's Cancer Research Group, Jennie Thomas and the Hunter Medical Research Institute. The National Study of Endometrial Cancer Genetics (NSECG) Group was supported principally by Cancer Research UK and by funds from the Oxford Comprehensive Biomedical Research Centre, with core infrastructure support to the Wellcome Trust Centre for Human Genetics, Oxford provided by grant 075491/Z/04. The Polish Endometrial Cancer Study (PECS) was funded by the intramural research program at the US National Cancer Institute, Division of Cancer Epidemiology and Genetics in the Hormonal and Reproductive Epidemiology Branch. The Singapore and Swedish Breast/Endometrial Cancer Study (SASBAC) was supported by funding from the Agency for Science, Technology and Research of Singapore (A*STAR), the US National Institutes of Health (NIH) and the Susan G. Komen Breast Cancer Foundation. The Shanghai Endometrial Cancer Genetic Study (SECGS) was supported by grants from the National Cancer Institute of the United States Public Health Service (RO1 CA 092585 and R01 CA90899, R01 CA64277). SEARCH is funded by a program grant from Cancer Research UK (C490/A10124).

Author information

Author notes

  1. Shahana Ahmed, Kaltin Ferguson, Catherine S Healey, Tracy O'Mara and Yong-Bing Xiang: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

    Amanda B Spurdle, Kaltin Ferguson, Tracy O'Mara, Logan C Walker, Paul Fahey, Grant W Montgomery & Penelope M Webb

  2. Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK

    Deborah J Thompson, Jonathan Morrison, Kyriaki Michailidou, Paul D Pharoah & Douglas F Easton

  3. Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK

    Shahana Ahmed, Catherine S Healey, Mitul Shah, Paul D Pharoah, Alison M Dunning & Douglas F Easton

  4. Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

    Tracy O'Mara

  5. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

    Stephen B Montgomery & Emmanouil T Dermitzakis

  6. Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA

    Peter A Fasching

  7. Institute of Human Genetics, Friedrich Alexander University Erlangen Nürnberg, Erlangen, Germany

    Matthias W Beckmann & Arif B Ekici

  8. Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen Nürnberg, Erlangen, Germany

    Alexander Hein

  9. University Gynecologic Oncology Center, Comprehensive Cancer Centre, Erlangen Nürnberg, Erlangen, Germany

    Alexander Hein

  10. Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium

    Diether Lambrechts

  11. Vesalius Research Center, University of Leuven, Leuven, Belgium

    Diether Lambrechts

  12. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium

    Lieve Coenegrachts, Ignace Vergote & Frederic Amant

  13. Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway

    Helga B Salvesen, Jone Trovik, Tormund S Njolstad & Harald Helland

  14. Department of Clinical Medicine, The University of Bergen, Bergen, Norway

    Helga B Salvesen, Jone Trovik & Tormund S Njolstad

  15. The Centre for Information Based Medicine and the Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, New South Wales (NSW), Australia

    Rodney J Scott & Katie Ashton

  16. The Hunter Medical Research Institute, John Hunter Hospital, NSW, Australia

    Rodney J Scott & Katie Ashton

  17. Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, NSW, Australia

    Rodney J Scott

  18. Hunter Centre for Gynaecological, John Hunter Hospital, NSW, Australia.,

    Rodney J Scott

  19. School of Medicine and Public Health, Faculty of Health, University of Newcastle, NSW, Australia.,

    Tony Proietto & Geoffrey Otton

  20. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Ian Tomlinson, Maggie Gorman & Kimberley Howarth

  21. Department of Clinical Genetics, St. George's Hospital Medical School, London, UK

    Shirley Hodgson

  22. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA

    Montserrat Garcia-Closas, Nicolas Wentzensen, Hannah Yang & Stephen Chanock

  23. Institute of Cancer Research, London, UK

    Montserrat Garcia-Closas

  24. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Per Hall, Kamila Czene & Jingmei Li

  25. Human Genetics, Genome Institute of Singapore, Singapore

    Jianjun Liu & Jingmei Li

  26. Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Xiao-Ou Shu, Wei Zheng & Jirong Long

  27. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

    Yong-Bing Xiang

Authors
  1. Amanda B Spurdle
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  2. Deborah J Thompson
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  3. Shahana Ahmed
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  7. Logan C Walker
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  37. Per Hall
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Consortia

The Australian National Endometrial Cancer Study Group

National Study of Endometrial Cancer Genetics Group

Contributions

A.B.S., D.F.E., G.M. and P.M.W. obtained funding for the study. A.B.S. and D.F.E. designed the study. A.B.S. and D.J.T. drafted the manuscript. P.F. and K.M. conducted preliminary analysis, and D.F.E. and D.J.T. conducted the final statistical analyses. A.B.S. and P.M.W. coordinated the ANECS. P.D.P. and D.F.E. coordinated Studies of Epidemiology and Risk Factors in Cancer Heredity (SEARCH). A.B.S., K.F. and T.O. coordinated the ANECS stage 1 genotyping. A.M.D., S.A. and C.S.H. coordinated the SEARCH stage 1 genotyping. L.C.W., S.B.M. and E.T.D. conducted analyses to assess correlations between genotype and gene expression. J.M. provided data management and bioinformatics support. T.O. and K.F. coordinated the ANECS and other Brisbane-based stage 2 genotyping and assisted with data management. S.A., C.S.H. and A.M.D. coordinated the stage 2 genotyping of the SEARCH samples. M.S. coordinated overall management of data for SEARCH samples. D.L., P.H., K.C., J. Liu, J. Li, I.T., K.H., M.G.-C., N.W., H.Y., S.C., X.-O.S. and J. Long coordinated the stage 2 genotyping, or extraction of existing genotype data, for the LES, SASBAC, NSECG, PECS and SECGS samples. The following authors coordinated the baseline studies and/or extraction of questionnaire and clinical information for studies included in stage 2 analysis: BECS (P.A.F., M.W.B., A.H. and A.B.E.); LES (D.L., L.C., I.V. and F.A.); MoMaTEC (H.B.S., J.T., H.H. and T.S.N.); NECS (R.J.S., K.A., T.P. and G.O.); NSECG (I.T., K.H., M.G. and S.H.); PECS (M.G.-C., H.Y. and N.W.); SASBAC (P.H., K.C., and J. Li); SECGS (X.-O.S. and W.Z. (principal investigators), J. Long (principal study geneticist) and Y.-B.X. (site principal investigator at the Shanghai Cancer Institute)). All authors provided critical review of the manuscript.

Corresponding author

Correspondence to Amanda B Spurdle.

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The authors declare no competing financial interests.

Additional information

A full list of members is provided in the Supplementary Note.

A full list of members is provided in the Supplementary Note.

Supplementary information

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Supplementary Note, Supplementary Figures 1 and 2 and Supplementary Tables 1–7. (PDF 232 kb)

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Spurdle, A., Thompson, D., Ahmed, S. et al. Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nat Genet 43, 451–454 (2011). https://doi.org/10.1038/ng.812

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