Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & (eds.) Vitiligo (Springer, Heidelberg & New York, 2010).

  2. 2.

    et al. Pigment Cell Res. 16, 208–214 (2003).

  3. 3.

    The genetics of generalized vitiligo. Curr. Dir. Autoimmun. 10, 244–257 (2008).

  4. 4.

    et al. New Engl. J. Med. 362, 1686–1697 (2010).

  5. 5.

    et al. Am. J. Hum. Genet. 81, 559–575 (2007).

  6. 6.

    et al. Genet. Epidemiol. 26, 61–69 (2004).

  7. 7.

    The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  8. 8.

    et al. Nat. Immunol. 7, 819–826 (2006).

  9. 9.

    et al. Blood 115, 510–518 (2010).

  10. 10.

    et al. Blood 112, 4699–4711 (2008).

  11. 11.

    , & Immunol. Res. 38, 112–121 (2007).

  12. 12.

    et al. Immunity 24, 623–632 (2006).

  13. 13.

    et al. Nat. Genet. 40, 955–962 (2008).

  14. 14.

    , , & J. Invest. Dermatol. 130, 798–803 (2010).

  15. 15.

    et al. Am. J. Hum. Genet. 57, 911–919 (1995).

Download references

Acknowledgements

We thank the membership of Vitiligo Support International, the Vitiligo Society, the National Vitiligo Foundation, the American Vitiligo Research Foundation and Associazione Ricerca Informazione per la Vitiligine for their enthusiastic participation. Supported by grants AR45584 and AR056292 from the US National Institutes of Health.

Author information

Affiliations

  1. Human Medical Genetics Program, University of Colorado School of Medicine, Aurora, Colorado, USA.

    • Ying Jin
    • , Stanca A Birlea
    • , Pamela R Fain
    • , Christina M Mailloux
    • , Sheri L Riccardi
    • , Katherine Gowan
    • , Paulene J Holland
    •  & Richard A Spritz
  2. Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

    • Ying Jin
    • , Pamela R Fain
    •  & Richard A Spritz
  3. Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado, USA.

    • Stanca A Birlea
  4. Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.

    • Pamela R Fain
  5. Division of Basic Medical Sciences, St. George's, University of London, London, UK.

    • Dorothy C Bennett
  6. Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.

    • Margaret R Wallace
  7. Department of Pathology, Immunology, & Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

    • Wayne T McCormack
  8. Department of Human Metabolism, School of Medicine, University of Sheffield, Sheffield, UK.

    • E Helen Kemp
    •  & Anthony P Weetman
  9. Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK.

    • David J Gawkrodger
  10. Laboratorio Fisiopatologia Cutanea, Istituto Dermatologico San Gallicano, Rome, Italy.

    • Mauro Picardo
    •  & Giovanni Leone
  11. Centre de Référence des maladies rares de la peau, Department of Dermatology, Hôpital St-André, Bordeaux, France.

    • Alain Taïeb
    • , Thomas Jouary
    •  & Khaled Ezzedine
  12. Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

    • Nanny van Geel
    •  & Jo Lambert
  13. Lumiderm, Madrid, Spain.

    • Andreas Overbeck

Authors

  1. Search for Ying Jin in:

  2. Search for Stanca A Birlea in:

  3. Search for Pamela R Fain in:

  4. Search for Christina M Mailloux in:

  5. Search for Sheri L Riccardi in:

  6. Search for Katherine Gowan in:

  7. Search for Paulene J Holland in:

  8. Search for Dorothy C Bennett in:

  9. Search for Margaret R Wallace in:

  10. Search for Wayne T McCormack in:

  11. Search for E Helen Kemp in:

  12. Search for David J Gawkrodger in:

  13. Search for Anthony P Weetman in:

  14. Search for Mauro Picardo in:

  15. Search for Giovanni Leone in:

  16. Search for Alain Taïeb in:

  17. Search for Thomas Jouary in:

  18. Search for Khaled Ezzedine in:

  19. Search for Nanny van Geel in:

  20. Search for Jo Lambert in:

  21. Search for Andreas Overbeck in:

  22. Search for Richard A Spritz in:

Contributions

Y.J. performed statistical analyses. K.G. managed computer databases and genotype data. S.L.R. and C.M.M. managed DNA samples and contributed to experimental procedures. P.J.H. managed subject coordination. S.A.B., D.C.B., M.R.W., W.T.M., E.H.K., D.J.G., A.P.W., M.P., G.L., A.T., T.J., K.E., N.v.G., J.L. and A.O. provided subject samples and phenotype information. P.R.F. and R.A.S. oversaw and managed all aspects of the study. R.A.S. wrote the first draft of the manuscript. All authors contributed to the final paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Richard A Spritz.

Supplementary information

PDF files

  1. 1.

    Supplementary Text and Figures

    Supplementary Methods and Supplementary Tables 1–3

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/ng.602

Further reading