Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
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Levey, A.S. et al. Kidney Int. 72, 247–259 (2007).
Köttgen, A. et al. Nat. Genet. 41, 712–717 (2009).
Kopp, J.B. et al. Nat. Genet. 40, 1175–1184 (2008).
Stevens, L.A., Coresh, J., Greene, T. & Levey, A.S. N. Engl. J. Med. 354, 2473–2483 (2006).
Price, A.L. et al. Nat. Genet. 38, 904–909 (2006).
Dyda, F., Klein, D.C. & Hickman, A.B. Annu. Rev. Biophys. Biomol. Struct. 29, 81–103 (2000).
Kharasch, E.D. Clin. Pharmacol. Ther. 84, 158–162 (2008).
Lash, L.H., Fisher, J.W., Lipscomb, J.C. & Parker, J.C. Environ. Health Perspect. 108 Suppl 2, 177–200 (2000).
Marshall, J.D., Beck, S., Maffei, P. & Naggert, J.K. Eur. J. Hum. Genet. 15, 1193–1202 (2007).
Mattoo, A. & Goldfarb, D.S. Semin. Nephrol. 28, 181–191 (2008).
Ciccia, A. et al. Mol. Cell 25, 331–343 (2007).
Fujita, T., Urban, T.J., Leabman, M.K., Fujita, K. & Giacomini, K.M. J. Pharm. Sci. 95, 25–36 (2006).
Filipski, K.K., Mathijssen, R.H., Mikkelsen, T.S., Schinkel, A.H. & Sparreboom, A. Clin. Pharmacol. Ther. 86, 396–402 (2009).
Naiche, L.A., Harrelson, Z., Kelly, R.G. & Papaioannou, V.E. Annu. Rev. Genet. 39, 219–239 (2005).
Chapman, D.L. et al. Dev. Dyn. 206, 379–390 (1996).
Study-specific acknowledgments are provided in the Supplementary Note. We thank S. Asquith and J. Collier at K-bioscience for their help with the replication genotyping.
The authors declare no competing financial interests.
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Chambers, J., Zhang, W., Lord, G. et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet 42, 373–375 (2010). https://doi.org/10.1038/ng.566
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