Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
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Study-specific acknowledgments are provided in the Supplementary Note. We thank S. Asquith and J. Collier at K-bioscience for their help with the replication genotyping.
The authors declare no competing financial interests.
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Chambers, J., Zhang, W., Lord, G. et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet 42, 373–375 (2010). https://doi.org/10.1038/ng.566
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