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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Nature Genetics volume 42, pages 224–228 (2010)Cite this article

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Abstract

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 × 10−11, per-allele odds ratio (OR) 1.26, 95% CI 1.18–1.35) and rs9564966 (P = 5.86 × 10−8, per-allele OR 1.21, 95% CI 1.13–1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 × 10−10, per-allele OR 0.77, 95% CI 0.71–0.84). A single SNP, rs401681 (P = 3.66 × 10−7, per-allele OR 1.19, 95% CI 1.11–1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

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Figure 1: Association results, recombination and linkage disequilibrium plots for 13q22.1, 1q32.1 and 5p15.33.

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References

  1. Ferlay, J., Bray, F., Pisani, P. & Parkin, D.M. GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide. IARC CancerBase vol. 5 (IARCPress, Lyon, 2004).

  2. Anderson, K.E., Mack, T.M. & Silverman, D. Cancer of the pancreas. in Cancer Epidemiology and Prevention (ed. Schottenfeld, D. & Fraumeni, J.J.) 721–762 (Oxford University Press, New York, (2006)).

  3. Shi, C., Hruban, R.H. & Klein, A.P. Familial pancreatic cancer. Arch. Pathol. Lab. Med. 133, 365–374 (2009).

    PubMed  PubMed Central  Google Scholar 

  4. Jones, S. et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324, 217 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tischkowitz, M.D. et al. Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer. Gastroenterology 137, 1183–1186 (2009).

    Article  PubMed  Google Scholar 

  6. Amundadottir, L. et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat. Genet. 41, 986–990 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661–678 (2007).

  8. Li, Y., Sung, W.K. & Liu, J.J. Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows. Am. J. Hum. Genet. 80, 705–715 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Yu, Z. & Schaid, D.J. Sequential haplotype scan methods for association analysis. Genet. Epidemiol. 31, 553–564 (2007).

    Article  PubMed  Google Scholar 

  10. Dong, J.T. & Chen, C. Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell. Mol. Life Sci. 66, 2691–2706 (2009).

    Article  CAS  PubMed  Google Scholar 

  11. Nakamura, Y. et al. Kruppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. Int. J. Cancer 125, 1859–1867 (2009).

    Article  CAS  PubMed  Google Scholar 

  12. Chen, C. et al. Defining a common region of deletion at 13q21 in human cancers. Genes Chromosom. Cancer 31, 333–344 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. Baudis, M. & Cleary, M.L. Progenetix.net: an online repository for molecular cytogenetic aberration data. Bioinformatics 17, 1228–1229 (2001).

    Article  CAS  PubMed  Google Scholar 

  14. Kainu, T. et al. Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus. Proc. Natl. Acad. Sci. USA 97, 9603–9608 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Paré, J.F. et al. The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J. Biol. Chem. 279, 21206–21216 (2004).

    Article  PubMed  Google Scholar 

  16. Lee, Y.K. & Moore, D.D. Liver receptor homolog-1, an emerging metabolic modulator. Front. Biosci. 13, 5950–5958 (2008).

    Article  CAS  PubMed  Google Scholar 

  17. Botrugno, O.A. et al. Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol. Cell 15, 499–509 (2004).

    Article  CAS  PubMed  Google Scholar 

  18. Yamamoto, K., Okamoto, A., Isonishi, S., Ochiai, K. & Ohtake, Y. A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. Biochem. Biophys. Res. Commun. 280, 1148–1154 (2001).

    Article  CAS  PubMed  Google Scholar 

  19. Bodnar, A.G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349–352 (1998).

    Article  CAS  PubMed  Google Scholar 

  20. Hahn, W.C. et al. Creation of human tumor cells with defined genetic elements. Nature 400, 464–468 (1999).

    Article  CAS  PubMed  Google Scholar 

  21. Kim, N.W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011–2015 (1994).

    Article  CAS  PubMed  Google Scholar 

  22. Wang, Y. et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat. Genet. 40, 1407–1409 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. McKay, J.D. et al. Lung cancer susceptibility locus at 5p15.33. Nat. Genet. 40, 1404–1406 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Rafnar, T. et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat. Genet. 41, 221–227 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Stacey, S.N. et al. New common variants affecting susceptibility to basal cell carcinoma. Nat. Genet. 41, 909–914 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Shete, S. et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat. Genet. 41, 899–904 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Landi, M.T. et al. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am. J. Hum. Genet. 85, 679–691 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Zienolddiny, S. et al. The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. Carcinogenesis 30, 1368–1371 (2009).

    Article  CAS  PubMed  Google Scholar 

  29. Calado, R.T. et al. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc. Natl. Acad. Sci. USA 106, 1187–1192 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Savage, S.A. & Alter, B.P. Dyskeratosis congenita. Hematol. Oncol. Clin. North Am. 23, 215–231 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  31. Yamaguchi, H. et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N. Engl. J. Med. 352, 1413–1424 (2005).

    Article  CAS  PubMed  Google Scholar 

  32. Calle, E.E. et al. The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer 94, 2490–2501 (2002).

    Article  PubMed  Google Scholar 

  33. The ATBC Cancer Prevention Study Group. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann. Epidemiol. 4, 1–10 (1994).

  34. Riboli, E. et al. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr. 5, 1113–1124 (2002).

    Article  CAS  PubMed  Google Scholar 

  35. Gallicchio, L. et al. Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland. Am. J. Epidemiol. 167, 807–813 (2008).

    Article  PubMed  Google Scholar 

  36. Wolpin, B.M. et al. Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Cancer Res. 67, 7923–7928 (2007).

    Article  CAS  PubMed  Google Scholar 

  37. Zeleniuch-Jacquotte, A. et al. Postmenopausal levels of sex hormones and risk of breast carcinoma in situ: results of a prospective study. Int. J. Cancer 114, 323–327 (2005).

    Article  CAS  PubMed  Google Scholar 

  38. Hayes, R.B. et al. Methods for etiologic and early marker investigations in the PLCO trial. Mutat. Res. 592, 147–154 (2005).

    Article  CAS  PubMed  Google Scholar 

  39. Anderson, G.L. et al. Implementation of the Women's Health Initiative study design. Ann. Epidemiol. 13, S5–S17 (2003).

    Article  PubMed  Google Scholar 

  40. Rexrode, K.M., Lee, I.M., Cook, N.R., Hennekens, C.H. & Buring, J.E. Baseline characteristics of participants in the Women's Health Study. J. Womens Health Gend. Based Med. 9, 19–27 (2000).

    Article  CAS  PubMed  Google Scholar 

  41. Eppel, A., Cotterchio, M. & Gallinger, S. Allergies are associated with reduced pancreas cancer risk: a population-based case-control study in Ontario, Canada. Int. J. Cancer 121, 2241–2245 (2007).

    Article  CAS  PubMed  Google Scholar 

  42. Duell, E.J. et al. Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Cancer Epidemiol. Biomarkers Prev. 17, 1470–1479 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Hassan, M.M. et al. Risk factors for pancreatic cancer: case-control study. Am. J. Gastroenterol. 102, 2696–2707 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  44. Olson, S.H. et al. Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer. Cancer Detect. Prev. 31, 345–351 (2007).

    Article  CAS  PubMed  Google Scholar 

  45. Risch, H.A. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J. Natl. Cancer Inst. 95, 948–960 (2003).

    Article  CAS  PubMed  Google Scholar 

  46. McWilliams, R.R. et al. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res. 68, 4928–4935 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Wigginton, J.E., Cutler, D.J. & Abecasis, G.R. A note on exact tests of Hardy-Weinberg equilibrium. Am. J. Hum. Genet. 76, 887–893 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. de Bakker, P.I. et al. Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum. Mol. Genet. 17, R122–R128 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Pritchard, J.K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. Genetics 155, 945–959 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Frazer, K.A. et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851–861 (2007).

    Article  CAS  PubMed  Google Scholar 

  51. Thomas, G. et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat. Genet. 40, 310–315 (2008).

    Article  CAS  PubMed  Google Scholar 

  52. Hunter, D.J. et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet. 39, 870–874 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Yu, K. et al. Population substructure and control selection in genome-wide association studies. PLoS One 3, e2551 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  54. Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904–909 (2006).

    Article  CAS  PubMed  Google Scholar 

  55. Patterson, N., Price, A.L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  56. Sun, L., Wilder, K. & McPeek, M.S. Enhanced pedigree error detection. Hum. Hered. 54, 99–110 (2002).

    Article  PubMed  Google Scholar 

  57. Clayton, D. Testing for association on the X chromosome. Biostatistics 9, 593–600 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  58. Lettre, G., Lange, C. & Hirschhorn, J.N. Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet. Epidemiol. 31, 358–362 (2007).

    Article  PubMed  Google Scholar 

  59. Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539–1558 (2002).

    Article  PubMed  Google Scholar 

  60. Fearnhead, P. SequenceLDhot: detecting recombination hotspots. Bioinformatics 22, 3061–3066 (2006).

    Article  CAS  PubMed  Google Scholar 

  61. Fearnhead, P., Harding, R.M, Schneider, J.A, Myers, S. & Donnelly, P. Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots. Genetics 167, 2067–2081 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Crawford, D.C. et al. Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat. Genet. 36, 700–706 (2004).

    Article  CAS  PubMed  Google Scholar 

  63. Li, N.P. & Stephens, M. Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data. Genetics 165, 2213–2233 (2003).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge the energy and contribution of our late colleague Sheila Bingham. Additional acknowledgments are in the Supplementary Note.

Author information

Author notes

  1. Gloria M Petersen, Laufey Amundadottir, Charles S Fuchs, Peter Kraft, Rachael Z Stolzenberg-Solomon, Robert N Hoover, Patricia Hartge and Stephen J Chanock: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA

    Gloria M Petersen, William R Bamlet, Mariza de Andrade & Robert R McWilliams

  2. Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Laufey Amundadottir, Hemang Parikh & Stephen J Chanock

  3. Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Laufey Amundadottir, Rachael Z Stolzenberg-Solomon, Kevin B Jacobs, Demetrius Albanes, Amy Hutchinson, Julie B Mendelsohn, Hemang Parikh, Gilles Thomas, Geoffrey S Tobias, Zhaoming Wang, Kai Yu, Joseph F Fraumeni Jr, Robert N Hoover, Patricia Hartge & Stephen J Chanock

  4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Charles S Fuchs & Brian M Wolpin

  5. Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Charles S Fuchs, Edward L Giovannucci, Susan E Hankinson, David J Hunter & Brian M Wolpin

  6. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

    Peter Kraft, Edward L Giovannucci, Susan E Hankinson, David J Hunter, Dominique S Michaud & Dimitrios Trichopoulos

  7. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA

    Peter Kraft

  8. Core Genotyping Facility, SAIC-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland, USA

    Kevin B Jacobs, Amy Hutchinson & Zhaoming Wang

  9. Bioinformed Consulting Services, Gaithersburg, Maryland, USA

    Kevin B Jacobs

  10. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA

    Alan A Arslan

  11. Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA

    Alan A Arslan & Anne Zeleniuch-Jacquotte

  12. New York University Cancer Institute, New York, New York, USA

    Alan A Arslan & Anne Zeleniuch-Jacquotte

  13. The Netherlands and Department of Gastroenterology and Hepatology, National Institute for Public Health and the Environment (RIVM), Bilthoven, University Medical Centre Utrecht, Utrecht, The Netherlands

    H Bas Bueno-de-Mesquita

  14. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    Steven Gallinger

  15. Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

    Myron Gross

  16. Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA

    Kathy Helzlsouer

  17. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA

    Elizabeth A Holly & Paige M Bracci

  18. Department of Epidemiology, American Cancer Society, Atlanta, Georgia, USA

    Eric J Jacobs & Alpa V Patel

  19. Department of Oncology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Alison P Klein

  20. Department of Epidemiology, Bloomberg School of Public Health, The Sol Goldman Pancreatic Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    Alison P Klein

  21. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    Andrea LaCroix, Margaret T Mandelson & Charles Kooperberg

  22. Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Donghui Li & Manal Hassan

  23. Group Health Center for Health Studies, Seattle, Washington, USA

    Margaret T Mandelson

  24. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Sara H Olson

  25. Yale University School of Public Health, New Haven, Connecticut, USA

    Harvey A Risch & Herbert Yu

  26. Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA

    Wei Zheng & Xiao-Ou Shu

  27. Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Christine D Berg

  28. Inserm, Paris-Sud University, Institut Gustave-Roussy, Villejuif, France

    Marie-Christine Boutron-Ruault

  29. Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Julie E Buring

  30. Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA

    Julie E Buring

  31. German Cancer Research Center (DKFZ), Heidelberg, Germany

    Federico Canzian & Rudolf Kaaks

  32. Johns Hopkins Bloomberg School of Public Health, George W. Comstock Center for Public Health Research and Prevention, Hagerstown, Maryland, USA

    Sandra Clipp

  33. Cancer Care Ontario and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

    Michelle Cotterchio

  34. Catalan Institute of Oncology (ICO), Barcelona, Spain

    Eric J Duell & Mazda Jenab

  35. Divisions of Aging, Department of Medicine, Physicians' Health Study, Cardiovascular Disease, and Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

    J Michael Gaziano

  36. Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA

    J Michael Gaziano

  37. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA

    Edward L Giovannucci

  38. Departments of Oncology, Pathology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Michael Goggins

  39. Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden

    Göran Hallmans

  40. MedStar Research Institute, Georgetown University, Hyattsville, Maryland, USA

    Barbara Howard

  41. Nutritional Epidemiology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumoridi Milano, Milan, Italy

    Vittorio Krogh

  42. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Robert C Kurtz

  43. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA

    Shannon M Lynch & Daniela Seminara

  44. Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK

    Dominique S Michaud, Petra H M Peeters & Elio Riboli

  45. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

    Petra H M Peeters

  46. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Aleksandar Rajkovic

  47. Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain

    Laudina Rodriguez

  48. Synergie-Lyon-Cancer, Inserm, Centre Leon Berard, Lyon, Cedex, France

    Gilles Thomas

  49. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark

    Anne Tjønneland

  50. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece

    Dimitrios Trichopoulos

  51. Division of Research, Kaiser Permanente, Northern California Region, Oakland, California, USA

    Stephen K Van Den Eeden

  52. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

    Jarmo Virtamo

  53. Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA

    Jean Wactawski-Wende

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  1. Gloria M Petersen
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  2. Laufey Amundadottir
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  7. Alan A Arslan
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  9. Steven Gallinger
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  12. Elizabeth A Holly
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  13. Eric J Jacobs
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  14. Alison P Klein
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  16. Donghui Li
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  18. Sara H Olson
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  19. Harvey A Risch
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  27. Federico Canzian
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  28. Sandra Clipp
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  29. Michelle Cotterchio
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  30. Mariza de Andrade
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  31. Eric J Duell
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  37. Manal Hassan
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  38. Barbara Howard
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  40. Amy Hutchinson
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Contributions

G.M.P., L.A., C.S.F., P.K., R.Z.S.-S., K.B.J., S.M.L., J.B.M., G.S.T., R.N.H., P.H. and S.J.C. organized and designed the study. L.A., A.H., K.B.J., G.T. and S.J.C. supervised genotyping of samples. L.A., P.K., R.Z.S.-S., C.S.F., K.B.J., C.K., H.P., Z.W., K.Y., R.N.H., P.H. and S.J.C. contributed to the design and execution of statistical analysis. L.A., G.M.P., P.K., R.Z.S.-S., R.N.H., P.H. and S.J.C. wrote the first draft of the manuscript. G.M.P., C.S.F., R.Z.S.-S., A.A.A., H.B.B., S.G., M.G., K.H., E.A.H., E.J.J., A.P.K., A.L., D.L., M.T.M., S.H.O., H.A.R., W.Z., D.A., W.R.B., C.D.B., M.-C.B.-R., J.E.B., P.M.B., F.C., S.C., M.C., M.deA., E.J.D., J.M.G., E.L.G., M.G., G.H., S.E.H., M.H., B.H., D.J.H., M.J., R.K., V.K., R.C.K., R.R.M., D.S.M., A.V.P., P.H.M.P., A.R., E.R., L.R., X.-O.S., A.T., D.T., S.K.V.D.E., J.V., J.W.-W., B.M.W., H.Y., A.Z.-J. and J.F.F.Jr. conducted the epidemiologic studies and contributed samples to the PanScan GWAS and/or replication. All authors contributed to the writing of the manuscript.

Corresponding author

Correspondence to Stephen J Chanock.

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The authors declare no competing financial interests.

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Petersen, G., Amundadottir, L., Fuchs, C. et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42, 224–228 (2010). https://doi.org/10.1038/ng.522

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