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Multiple loci on 8q24 associated with prostate cancer susceptibility


Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10−8; rs620861: OR = 0.90, P = 4.8 × 10−8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

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Figure 1: The 8q24 region.


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Acknowledgments are presented in the Supplementary Note.

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Authors and Affiliations




A.A.A.O. and D.F.E. performed the statistical analysis and drafted the manuscript with major input from R.A.E. and Z.K.-J. R.A.E. and D.F.E. are joint PIs on this study. M.G. provided data management for the UK Genetic Prostate Cancer Study study. J.M. provided database and bioinformatics support. G.G.G., J.L.H. and D.R.E. are principal investigators (PIs) of the Australian studies; J.L.D., F.C.H. and D.E.N. are joint PIs of ProtecT. M.C.S. led the Australian genotyping. G.S. coordinated the Australian studies. Z.K.-J coordinated the genotyping in stage 2 with support from D.A.L., M.T., S.J. and E.S. K.R.M. and R.A.E. are joint PIs of the Prostate Cancer Research Fund study. D.P.D., A.T.A.-J., A.L.H., L.T.O'B., R.A.W., E.S., A.L., A.H., R.A.H., V.S.K., C.C.P., C.J.W., A.T., T.C., C.O. and C.C. identified and collected clinical material, processed samples, undertook genotyping or collated data. Other members of The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators, listed in the Supplementary Note, collected clinical samples and provided data management support.

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Correspondence to Douglas F Easton.

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Full lists of members are provided in the Supplementary Note.

Full lists of members are provided in the Supplementary Note.

Supplementary information

Supplementary Text and Figures

Supplementary Tables 2–10, Supplementary Methods and Supplementary Note. (PDF 532 kb)

Supplementary Table

Supplementary Table 1 (XLS 54 kb)

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Al Olama, A., Kote-Jarai, Z., Giles, G. et al. Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet 41, 1058–1060 (2009).

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