We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 × 10−10) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 × 10−15) and rs445114[T] (OR = 1.14, P = 4.7 × 10−10), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 × 10−11) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 × 10−12). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.

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We thank the individuals who participated in the study and whose contribution made this work possible. This project was funded in part by contract number 202059 (PROMARK) from the Seventh Framework Program of the European Union to deCODE Genetics (T.R. and L.A.K.), in part by FP7-MC-IAPP Grant agreement no. 218071 (CancerGene) to deCODE Genetics, in part by a V Foundation award and US Department of Veterans Affairs grants to J.R.S., and in part by Academy of Finland, Sigrid Juselius Foundation, Finnish Cancer Organisations and the Competitive Research Funding of the Pirkanmaa Hospital District, Tampere University Hospital, to J.S.

Author information

Author notes

    • Julius Gudmundsson
    •  & Patrick Sulem

    These authors contributed equally to this work.


  1. deCODE Genetics, Reykjavik, Iceland.

    • Julius Gudmundsson
    • , Patrick Sulem
    • , Daniel F Gudbjartsson
    • , Thorarinn Blondal
    • , Arnaldur Gylfason
    • , Droplaug N Magnusdottir
    • , Gudbjorg Orlygsdottir
    • , Margret Jakobsdottir
    • , Simon N Stacey
    • , Asgeir Sigurdsson
    • , Carlo Zanon
    • , Michael L Frigge
    • , Kristleifur Kristjansson
    • , Jeffrey R Gulcher
    • , Augustine Kong
    • , Unnur Thorsteinsdottir
    • , Thorunn Rafnar
    •  & Kari Stefansson
  2. Department of Pathology, Landspitali–University Hospital, Reykjavik, Iceland.

    • Bjarni A Agnarsson
    • , Kristrun R Benediktsdottir
    •  & Rosa B Barkardottir
  3. Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

    • Bjarni A Agnarsson
    • , Kristrun R Benediktsdottir
    • , Unnur Thorsteinsdottir
    •  & Kari Stefansson
  4. Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

    • Tiina Wahlfors
    •  & Johanna Schleutker
  5. Department of Urology, Tampere University Hospital, University of Tampere, Tampere, Finland.

    • Teuvo Tammela
  6. Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

    • Joan P Breyer
    • , Kate M McReynolds
    • , Kevin M Bradley
    •  & Jeffrey R Smith
  7. Health Science Institute of Aragon, Zaragoza, Spain.

    • Berta Saez
    • , Javier Godino
    •  & Jose I Mayordomo
  8. Nanotechnology Institute of Aragon, Zaragoza, Spain.

    • Berta Saez
    •  & Jose I Mayordomo
  9. Division of Radiation Oncology, Lozano Blesa University Hospital, University of Zaragoza, Zaragoza, Spain.

    • Sebastian Navarrete
    •  & Fernando Fuertes
  10. Division of Medical Oncology, Reina Sofia Hospital, Tudela, Spain.

    • Laura Murillo
  11. Division of Medical Oncology, Ernest Lluch Hospital, Calatayud, Spain.

    • Eduardo Polo
  12. Comprehensive Cancer Center East, Nijmegen, The Netherlands.

    • Katja K Aben
    •  & Lambertus A Kiemeney
  13. Department of Epidemiology, Biostatistics & Health Technology Assessment Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

    • Katja K Aben
  14. Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

    • Inge M van Oort
    •  & Lambertus A Kiemeney
  15. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.

    • Brian K Suarez
  16. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

    • Brian T Helfand
    • , Donghui Kan
    •  & William J Catalona
  17. Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy.

    • Carlo Zanon
  18. Department of Urology, Landspitali–University Hospital, Reykjavik, Iceland.

    • Gudmundur V Einarsson
    •  & Eirikur Jonsson
  19. Division of Medical Oncology, University Hospital, University of Zaragoza, Zaragoza, Spain.

    • Jose I Mayordomo
  20. Medical Research Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

    • Jeffrey R Smith


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The study was designed and results were interpreted by J. Gudmundsson, P.S., A.K., U.T., T.R. and K.S. Statistical analysis was carried out by P.S., D.F.G., J. Gudmundsson, M.L.F. and A.K. Subject recruitment, biological material collection and handling along with genotyping were supervised and carried out by J. Gudmundsson, B.A.A., K.R.B., T.B., A.G., D.N.M., G.O., M.J., S.N.S., A.S., T.W., T.T., J.P.B., K.M.M., K.M.B., B.S., J. Godino, S.N., F.F., L.M., E.P., K.K.A., I.M.v.O., B.K.S., B.T.H., D.K., C.Z., K.K., J.R.G., G.V.E., E.J., W.J.C., J.I.M., L.A.K., J.R.S., J.S., R.B.B., U.T. and T.R. Authors J. Gudmundsson, P.S., D.F.G., T.R. and K.S. drafted the manuscript. All authors contributed to the final version of the paper. Principal investigators and corresponding authors for the respective replication study populations are: The Netherlands, L.A.K.; Spain, J.I.M.; Chicago, W.J.C.; Nashville, Tenn., USA, J.R.S.; Finland, J.S.

Competing interests

The authors from deCODE in Reykjavik, Iceland are shareholders in deCODE Genetics, Inc.

Corresponding authors

Correspondence to Javier Godino or Kari Stefansson.

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