Identification of a new prostate cancer susceptibility locus on chromosome 8q24

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Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10−10, heterozygote OR = 1.17, 95% CI 1.10–1.24; homozygote OR = 1.33, 95% CI 1.21–1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

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Figure 1: LD structure and regional association results for 82 SNPs genotyped over 314 kb of chromosome 8q24.

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Acknowledgements

This project was funded in part using grants CA129684 to J.X. and CA131338 to S.L.Z. This project was funded in whole or in part with federal funds from the NCI, National Institutes of Health (NIH), under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services (DHHS), nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

Author information

M.Y., N.C. and S.J.C. drafted the manuscript; N.C., J.C., K.B.J., Z.W. and M.Y. performed statistical analyses; K.B.J., N.C., J.G.-B., P.K., S.W., N.O., K.Y. and L.A. made important suggestions to the analytic plan and/or aided interpretation of results; A.H. led the genotyping efforts; R.B.H., S.B., H.S.F., M.J.T., W.R.D., D.A., J.V., S.W., F.R.S., G.C.-T., O.C., A.V., G.L.A., E.D.C., C.A.H., B.H., L.K., L.L.M., A.S., E.R., T.J.K., R.K., W.I., S.I., K.E.W., H.G., F.W., P.S., J.X., S.L.Z., J.S., L.J.V., K.H. and M.K. provided DNA or genotyping data for study subjects; M.T., D.S.G., R.N.H., J.F.F., D.J.H. and G.T. participated in revising the manuscript and provided important intellectual contributions.

Correspondence to Meredith Yeager.

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