Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mismatch repair prefers exons

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Differential DNA repair in exons as compared to introns.

Katie Vicari/Springer Nature

References

  1. Youssoufian, H. et al. Nature 324, 380–382 (1986).

    Article  CAS  Google Scholar 

  2. Carlson, J. et al. bioRxiv, preprint at https://doi.org/10.1101/108290 (2017).

  3. Sabarinathan, R., Mularoni, L., Deu-Pons, J., Gonzalez-Perez, A. & López-Bigas, N. Nature 532, 264–267 (2016).

    Article  CAS  Google Scholar 

  4. Perera, D. et al. Nature 532, 259–263 (2016).

    Article  CAS  Google Scholar 

  5. Schuster-Böckler, B. & Lehner, B. Nature 488, 504–507 (2012).

    Article  Google Scholar 

  6. Lawrence, M.S. et al. Nature 499, 214–218 (2013).

    Article  CAS  Google Scholar 

  7. Haradhvala, N.J. et al. Cell 164, 538–549 (2016).

    Article  CAS  Google Scholar 

  8. Jónsson, H. et al. Nature 549, 519–522 (2017).

    Article  Google Scholar 

  9. Frigola, J. et al. Nat. Genet. 49, 1684–1692 (2017).

    Article  CAS  Google Scholar 

  10. Li, J. et al. PLoS Comput. Biol. 11, e1004583 (2015).

    Article  Google Scholar 

  11. Li, F. et al. Cell 153, 590–600 (2013).

    Article  CAS  Google Scholar 

  12. Schwartz, S., Meshorer, E. & Ast, G. Nat. Struct. Mol. Biol. 16, 990–995 (2009).

    Article  CAS  Google Scholar 

  13. King, M.C. & Wilson, A.C. Science 188, 107–116 (1975).

    Article  CAS  Google Scholar 

  14. Supek, F. & Lehner, B. Cell 170, 534–547 (2017).

    Article  CAS  Google Scholar 

  15. Imielinski, M., Guo, G. & Meyerson, M. Cell 168, 460–472 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amnon Koren.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Massey, D., Koren, A. Mismatch repair prefers exons. Nat Genet 49, 1673–1674 (2017). https://doi.org/10.1038/ng.3993

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3993

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer