Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Mismatch repair prefers exons

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Differential DNA repair in exons as compared to introns.

Katie Vicari/Springer Nature


  1. 1

    Youssoufian, H. et al. Nature 324, 380–382 (1986).

    CAS  Article  Google Scholar 

  2. 2

    Carlson, J. et al. bioRxiv, preprint at (2017).

  3. 3

    Sabarinathan, R., Mularoni, L., Deu-Pons, J., Gonzalez-Perez, A. & López-Bigas, N. Nature 532, 264–267 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Perera, D. et al. Nature 532, 259–263 (2016).

    CAS  Article  Google Scholar 

  5. 5

    Schuster-Böckler, B. & Lehner, B. Nature 488, 504–507 (2012).

    Article  Google Scholar 

  6. 6

    Lawrence, M.S. et al. Nature 499, 214–218 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Haradhvala, N.J. et al. Cell 164, 538–549 (2016).

    CAS  Article  Google Scholar 

  8. 8

    Jónsson, H. et al. Nature 549, 519–522 (2017).

    Article  Google Scholar 

  9. 9

    Frigola, J. et al. Nat. Genet. 49, 1684–1692 (2017).

    CAS  Article  Google Scholar 

  10. 10

    Li, J. et al. PLoS Comput. Biol. 11, e1004583 (2015).

    Article  Google Scholar 

  11. 11

    Li, F. et al. Cell 153, 590–600 (2013).

    CAS  Article  Google Scholar 

  12. 12

    Schwartz, S., Meshorer, E. & Ast, G. Nat. Struct. Mol. Biol. 16, 990–995 (2009).

    CAS  Article  Google Scholar 

  13. 13

    King, M.C. & Wilson, A.C. Science 188, 107–116 (1975).

    CAS  Article  Google Scholar 

  14. 14

    Supek, F. & Lehner, B. Cell 170, 534–547 (2017).

    CAS  Article  Google Scholar 

  15. 15

    Imielinski, M., Guo, G. & Meyerson, M. Cell 168, 460–472 (2017).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Amnon Koren.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Massey, D., Koren, A. Mismatch repair prefers exons. Nat Genet 49, 1673–1674 (2017).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing