Mismatch repair prefers exons

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

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Figure 1: Differential DNA repair in exons as compared to introns.

Katie Vicari/Springer Nature

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Correspondence to Amnon Koren.

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Massey, D., Koren, A. Mismatch repair prefers exons. Nat Genet 49, 1673–1674 (2017). https://doi.org/10.1038/ng.3993

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