Supplementary Figure 1: Genomic alterations detectable in cfDNA of EGFR-mutant p.T790M-positive and p.T790M-negative patients. | Nature Genetics

Supplementary Figure 1: Genomic alterations detectable in cfDNA of EGFR-mutant p.T790M-positive and p.T790M-negative patients.

From: Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Supplementary Figure 1

(a-b) Lolliplots of gene level alterations in EGFR-mutant p.T790M mutant positive compared to EGFR-mutant p.T790M mutant negative samples. Alterations in AR and PDGFRA in cfDNA of EGFR-mutant p.T790M positive (n=440) and EGFR-mutant p.T790M mutant negative (n=682) are indicated. (c) Concurrent genomic alterations detectable in EGFR-mutant NSCLC patients encoding the EGFR p.C797S mutation. Frequency of non-synonymous genomic alterations of known or predicted functional significance: single nucleotide variants (SNV), copy number gains (CNG), insertions or deletions (INDEL), or gene rearrangements (FUSION) in cancer-related genes detectable by next-generation sequencing of circulating tumor DNA are indicated.

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