Supplementary Figure 8: Schematic of clonal evolution in a patient with EGFR-mutant lung adenocarcinoma. | Nature Genetics

Supplementary Figure 8: Schematic of clonal evolution in a patient with EGFR-mutant lung adenocarcinoma.

From: Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Supplementary Figure 8

Top panel displays the subclonal phylogeny over the course of the patient's disease with the two posited independent origins of the EGFR p.T790M SNV. Bottom panel shows the region specific subclonal phylogenies also shown in figure 5c. Below each sample phylogeny there is a “beehive” plot containing 100 hexagons that each represent 1% of the cells present in a sample. These illustrate the relationships between subclonal clusters by displaying their cellular prevalence in that sample. In a subclonal phylogeny each cluster linked to another is present in a subset of the cells containing the previous cluster. Therefore populations of cells will contain the mutations from multiple clusters and these can be considered subclones. The subclones present in a region are indicated to the right of the subclonal phylogeny for a sample and may contain multiple clusters of mutations. The prevalence of a subclone in each sample can be inferred from the proportion of hexagons the clusters that it consists of occupy.

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