Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Divergent evolutionary trajectories in transplanted tumor models

Nature Genetics volume 49, pages 1565–1566 (2017)Cite this article

Subjects

Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Patient-derived xenografts exhibit clonal evolution during serial passaging.

References

  1. Hidalgo, M. et al. Cancer Discov. 4, 998–1013 (2014).

    Article  CAS  Google Scholar 

  2. Rubio-Viqueira, B. & Hidalgo, M. Clin. Pharmacol. Ther. 85, 217–221 (2009).

    Article  CAS  Google Scholar 

  3. Gao, H. et al. Nat. Med. 21, 1318–1325 (2015).

    Article  CAS  Google Scholar 

  4. Ben-David, U. et al. Nat. Genet. 49, 1567–1575 (2017).

    Article  CAS  Google Scholar 

  5. Sia, D., Moeini, A., Labgaa, I. & Villanueva, A. Pharmacogenomics 16, 1671–1683 (2015).

    Article  CAS  Google Scholar 

  6. Hodgson, J.G. et al. Neuro-oncol. 11, 477–487 (2009).

    Article  CAS  Google Scholar 

  7. Aitman, T.J. et al. Nature 439, 851–855 (2006).

    Article  CAS  Google Scholar 

  8. Costello, J.C. et al. Nat. Biotechnol. 32, 1202–1212 (2014).

    Article  CAS  Google Scholar 

  9. Zitvogel, L., Pitt, J.M., Daillère, R., Smyth, M.J. & Kroemer, G. Nat. Rev. Cancer 16, 759–773 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Liver Diseases, Department of Medicine, Liver Cancer Research Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Carlos Villacorta-Martin, Amanda J Craig & Augusto Villanueva

  2. Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Augusto Villanueva

Authors
  1. Carlos Villacorta-Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amanda J Craig
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Augusto Villanueva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Augusto Villanueva.

Ethics declarations

Competing interests

A.V. receives research support from Champions Oncology.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Villacorta-Martin, C., Craig, A. & Villanueva, A. Divergent evolutionary trajectories in transplanted tumor models. Nat Genet 49, 1565–1566 (2017). https://doi.org/10.1038/ng.3983

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3983

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer