High-resolution maps of enhancer–promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes. This represents an important step forward for mapping genes involved in complex diseases.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk
Nature Communications Open Access 25 September 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 /Â 30Â days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Welter, D. et al. Nucleic Acids Res. 42, D1001–D1006 (2014).
Glinos, D.A. et al. Immunology http://dx.doi.org/10.1111/imm.12796 (2017).
Mumbach, M.R. et al. Nat. Genet. 49, 1602–1612 (2017).
Pombo, A. & Dillon, N. Nat. Rev. Mol. Cell Biol. 16, 245–257 (2015).
Mumbach, M.R. et al. Nat. Methods 13, 919–922 (2016).
Farh, K.K. et al. Nature 518, 337–343 (2015).
Trynka, G. et al. Nat. Genet. 45, 124–130 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Trynka, G. Enhancers looping to target genes. Nat Genet 49, 1564–1565 (2017). https://doi.org/10.1038/ng.3982
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3982
This article is cited by
-
Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk
Nature Communications (2023)