Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Polycomb silencing mediated by specific DNA-binding recruiters

Nature Genetics volume 49, pages 1416–1417 (2017)Cite this article

Subjects

Regulation of epigenetic factors through their recruitment to specific genomic regions is still poorly understood. A recent study demonstrates a global mechanism of tethering Polycomb group (PcG) proteins through sequence-specific DNA-binding factors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Recruitment of PRC2 to PREs in Drosophila and Arabidopsis.

References

  1. Mozgova, I. & Hennig, L. Annu. Rev. Plant Biol. 66, 269–296 (2015).

    Article  CAS  Google Scholar 

  2. Simon, J.A. & Kingston, R.E. Mol. Cell 49, 808–824 (2013).

    Article  CAS  Google Scholar 

  3. Bauer, M., Trupke, J. & Ringrose, L. Chromosoma 125, 471–496 (2016).

    Article  CAS  Google Scholar 

  4. Kassis, J.A. & Brown, J.L. Adv. Genet. 81, 83–118 (2013).

    Article  CAS  Google Scholar 

  5. Deng, W. et al. BMC Genomics 14, 593 (2013).

    Article  CAS  Google Scholar 

  6. Hecker, A. et al. Plant Physiol. 168, 1013–1024 (2015).

    Article  Google Scholar 

  7. Mu, Y. et al. Plant Cell Physiol. 58, 607–621 (2017).

    CAS  PubMed  Google Scholar 

  8. Xiao, J. et al. Nat. Genet. 49, 1546–1552 (2017).

    Article  CAS  Google Scholar 

  9. Abed, J.A. & Jones, R.S. Nat. Struct. Mol. Biol. 19, 1214–1215 (2012).

    Article  CAS  Google Scholar 

  10. Heo, J.B. & Sung, S. Science 331, 76–79 (2011).

    Article  CAS  Google Scholar 

  11. Sun, B. et al. Science 343, 1248559 (2014).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Plant & Agricultural Biosciences Centre (PABC), National University of Ireland Galway, Galway, Ireland

    Eduardo March & Sara Farrona

Authors
  1. Eduardo March
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sara Farrona
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sara Farrona.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

March, E., Farrona, S. Polycomb silencing mediated by specific DNA-binding recruiters. Nat Genet 49, 1416–1417 (2017). https://doi.org/10.1038/ng.3961

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3961

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research