Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer

Nature Genetics volume 49, pages 1294–1295 (2017)Cite this article

Subjects

ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Nucleus of a T2E-positive prostate cancer cell.

Debbie Maizels/Springer Nature

References

  1. Li, J. et al. Science 275, 1943–1947 (1997).

    Article  CAS  Google Scholar 

  2. Taylor, B.S. et al. Cancer Cell 18, 11–22 (2010).

    Article  CAS  Google Scholar 

  3. Berger, M.F. et al. Nature 470, 214–220 (2011).

    Article  CAS  Google Scholar 

  4. Tomlins, S.A. et al. Science 310, 644–648 (2005).

    Article  CAS  Google Scholar 

  5. Cancer Genome Atlas Research Network. Cell 163, 1011–1025 (2015).

  6. Tomlins, S.A. et al. Neoplasia 10, 177–188 (2008).

    Article  CAS  Google Scholar 

  7. Adamo, P. & Ladomery, M.R. Oncogene 35, 403–414 (2016).

    Article  CAS  Google Scholar 

  8. Kron, K.J. et al. Nat. Genet., 49 1336–1345 (2017)10.1038/ng.3930.

    Article  CAS  PubMed  Google Scholar 

  9. Whyte, W.A. et al. Cell 153, 307–319 (2013).

    Article  CAS  Google Scholar 

  10. Cao, F. et al. Sci. Rep. 7, 2186 (2017).

    Article  Google Scholar 

  11. Pott, S. & Lieb, J.D. Nat. Genet. 47, 8–12 (2015).

    Article  CAS  Google Scholar 

  12. Wang, Q. et al. Mol. Cell 27, 380–392 (2007).

    Article  Google Scholar 

  13. Babu, D. & Fullwood, M.J. Nucleus 6, 382–393 (2015).

    Article  CAS  Google Scholar 

  14. Wang, Q., Carroll, J.S. & Brown, M. Mol. Cell 19, 631–642 (2005).

    Article  CAS  Google Scholar 

  15. Rickman, D.S. et al. Proc. Natl. Acad. Sci. USA 109, 9083–9088 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Cancer Science Institute of Singapore, National University of Singapore, Singapore

    Deepak Babu & Melissa J Fullwood

  2. the School of Biological Sciences, Nanyang Technological University, Singapore, and the Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore

    Melissa J Fullwood

Authors
  1. Deepak Babu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Melissa J Fullwood
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Melissa J Fullwood.

Ethics declarations

Competing interests

M.J.F. declares two patents on chromatin interaction technologies.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Babu, D., Fullwood, M. Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer. Nat Genet 49, 1294–1295 (2017). https://doi.org/10.1038/ng.3944

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3944

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing