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Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer

ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.

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Figure 1: Nucleus of a T2E-positive prostate cancer cell.

Debbie Maizels/Springer Nature

References

  1. Li, J. et al. Science 275, 1943–1947 (1997).

    Article  CAS  Google Scholar 

  2. Taylor, B.S. et al. Cancer Cell 18, 11–22 (2010).

    Article  CAS  Google Scholar 

  3. Berger, M.F. et al. Nature 470, 214–220 (2011).

    Article  CAS  Google Scholar 

  4. Tomlins, S.A. et al. Science 310, 644–648 (2005).

    Article  CAS  Google Scholar 

  5. Cancer Genome Atlas Research Network. Cell 163, 1011–1025 (2015).

  6. Tomlins, S.A. et al. Neoplasia 10, 177–188 (2008).

    Article  CAS  Google Scholar 

  7. Adamo, P. & Ladomery, M.R. Oncogene 35, 403–414 (2016).

    Article  CAS  Google Scholar 

  8. Kron, K.J. et al. Nat. Genet., 49 1336–1345 (2017)10.1038/ng.3930.

    Article  CAS  PubMed  Google Scholar 

  9. Whyte, W.A. et al. Cell 153, 307–319 (2013).

    Article  CAS  Google Scholar 

  10. Cao, F. et al. Sci. Rep. 7, 2186 (2017).

    Article  Google Scholar 

  11. Pott, S. & Lieb, J.D. Nat. Genet. 47, 8–12 (2015).

    Article  CAS  Google Scholar 

  12. Wang, Q. et al. Mol. Cell 27, 380–392 (2007).

    Article  Google Scholar 

  13. Babu, D. & Fullwood, M.J. Nucleus 6, 382–393 (2015).

    Article  CAS  Google Scholar 

  14. Wang, Q., Carroll, J.S. & Brown, M. Mol. Cell 19, 631–642 (2005).

    Article  CAS  Google Scholar 

  15. Rickman, D.S. et al. Proc. Natl. Acad. Sci. USA 109, 9083–9088 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Melissa J Fullwood.

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M.J.F. declares two patents on chromatin interaction technologies.

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Babu, D., Fullwood, M. Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer. Nat Genet 49, 1294–1295 (2017). https://doi.org/10.1038/ng.3944

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