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Genetic insights into mammalian heart regeneration

Nature Genetics volume 49, pages 12921293 (2017) | Download Citation

Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury.

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Author information

Affiliations

  1. Ana Vujic, Vinícius Bassaneze and Richard T. Lee are at the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

    • Ana Vujic
    • , Vinícius Bassaneze
    •  & Richard T Lee

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Richard T Lee.

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DOI

https://doi.org/10.1038/ng.3942

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