(a,b) Thirty-nine genes were detected by SMR as being under the control of 29 causal variants that account for the association detected by GWAS and the eQTL effect reported in the Blood eQTL browser (Supplementary Table 4). The performance of the GRS verus TRS based on these genes is shown for disease status: comparison of samples with Crohn’s disease (n = 210) versus non-IBD controls (n = 35) (a) and disease course (3-year period after diagnosis): comparison of samples that remain in non-complicated Crohn’s disease (B1; n = 183) versus those that develop complicated disease (B2 and/or B3; n = 27) (b). The standardized GRS and TRS are shown on the y axis. Differences between groups (in s.d. units) along with P values (two-sided t test) are reported for each comparison.