(a,b) Each plot shows the TRS based on 157 IBD genes associated with 96 eQTLs that are also associated with IBD or in LD with a SNP associated with the disease (Supplementary Table 1). The discriminatory performance of the GRS versus TRS based on these genes is shown for disease status: comparison of samples with Crohn’s disease (n = 210) and controls (n = 35) (a) and disease course (3-year period after diagnosis): comparison of samples that remain in non-complicated Crohn’s disease (B1; n = 183) and those that develop complicated disease (B2 and/or B3; n = 27) (b). The standardized GRS and TRS are shown on the y axis. Differences between groups (in s.d. units) along with P values (two-sided t test) are reported for each comparison.