eQTLs detected in the vicinity of SNPs associated with IBD tend to show concordant effect size and direction in blood and ileum. The effects of 136 eQTLs available in ileum are shown (Supplementary Table 2). The x axis shows the β values for the eQTLs detected in peripheral blood from the Blood eQTL browser; the y axis shows the β values in the eQTL mapping study with ileal biopsies from the RISK study (see “Mapping study in the RISK cohort to build the ileal TRS” in the Online Methods). The dashed best-fitting least-squares regression line corresponds to Spearman r = 0.54 (P = 2 × 10−11). Values in the corners indicate the percentage of loci in each quadrant, showing that 70% are concordant in direction of effect in the two tissues (P = 1.7 × 10−6, sign test).