Supplementary Figure 6: Performance of PRSs based on LD-pruned variants at different significance inclusion thresholds. | Nature Genetics

Supplementary Figure 6: Performance of PRSs based on LD-pruned variants at different significance inclusion thresholds.

From: Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease

Supplementary Figure 6

(a,b) PRSs at different thresholds (Online Methods) successfully separate Crohn’s disease cases from non-IBD controls (a) but fail to distinguish according to development of complicated disease (b). The performance of PRSs using SNPs that pass a range of liberal P-value thresholds in GWAS analysis is shown (the inclusion threshold and total number of variants used are reported on the y axis). Differences between groups (in s.d. units) along with P values for each comparison are reported on the x axis.

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