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Monogenic immune disorders and severe atopic disease

Nature Genetics volume 49, pages 1162–1163 (2017)Cite this article

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Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

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Figure 1: Monogenic immune disorders and germline CARD11-opathies.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

    Catherine M Biggs, Henry Y Lu & Stuart E Turvey

  2. Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    Catherine M Biggs & Henry Y Lu

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  1. Catherine M Biggs
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  2. Henry Y Lu
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  3. Stuart E Turvey
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Correspondence to Stuart E Turvey.

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Biggs, C., Lu, H. & Turvey, S. Monogenic immune disorders and severe atopic disease. Nat Genet 49, 1162–1163 (2017). https://doi.org/10.1038/ng.3925

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