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Promoting transcription over long distances

Promoters and enhancers have long been regarded as distinct elements, a notion that has been challenged more recently. Two new studies now identify promoters that function as long-range enhancers in vivo to regulate the transcription of distal genes.

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Figure 1: Promoters regulate distal gene transcription.


  1. Kim, T.-K. & Shiekhattar, R. Cell 162, 948–959 (2015).

    Article  CAS  Google Scholar 

  2. Core, L.J. et al. Nat. Genet. 46, 1311–1320 (2014).

    Article  CAS  Google Scholar 

  3. Kowalczyk, M.S. et al. Mol. Cell 45, 447–458 (2012).

    Article  CAS  Google Scholar 

  4. Zabidi, M.A. et al. Nature 518, 556–559 (2015).

    Article  CAS  Google Scholar 

  5. Arnold, C.D. et al. Science 339, 1074–1077 (2013).

    Article  CAS  Google Scholar 

  6. Li, G. et al. Cell 148, 84–98 (2012).

    Article  CAS  Google Scholar 

  7. Diao, Y. et al. Nat. Methods 14, 629–635 (2017).

    Article  CAS  Google Scholar 

  8. Dao, L.T.M. et al. Nat. Genet. 49, 1073–1081 (2017).

    Article  CAS  Google Scholar 

  9. Rajagopal, N. et al. Nat. Biotechnol. 34, 167–174 (2016).

    Article  CAS  Google Scholar 

  10. Engreitz, J.M. et al. Nature 539, 452–455 (2016).

    Article  CAS  Google Scholar 

  11. Paralkar, V.R. et al. Mol. Cell 62, 104–110 (2016).

    Article  CAS  Google Scholar 

  12. Corrales-Berjano, M. et al. Genome Res. (2017).

  13. Birnbaum, R.Y. et al. Genome Res. 22, 1059–1068 (2012).

    Article  CAS  Google Scholar 

  14. Andersson, R. et al. Nature 507, 455–461 (2014).

    Article  CAS  Google Scholar 

  15. Arnold, C.D. et al. Nat. Biotechnol. 35, 136–144 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Alexander Stark.

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Catarino, R., Neumayr, C. & Stark, A. Promoting transcription over long distances. Nat Genet 49, 972–973 (2017).

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