News & Views | Published:

Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses

Nature Genetics volume 49, pages 974975 (2017) | Download Citation

A study in this issue demonstrates that epigenome-modifying drugs used in cancer chemotherapy induce transcription from thousands of previously unannotated transcription start sites, most of which are derived from ancient endogenous retroviruses (ERVs). This work, coupled with previous related findings, suggests that induction of ERVs, rather than direct effects on specific genes, may have a central role in the cellular responses to such agents and, in turn, their therapeutic efficacy.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Annu. Rev. Med. 67, 73–89 (2016).

  2. 2.

    , , & Leuk. Lymphoma 58, 1022–1036 (2017).

  3. 3.

    , , & BMC Genomics 16, 873 (2015).

  4. 4.

    & Brief. Funct. Genomics 12, 174–190 (2013).

  5. 5.

    et al. Nat. Genet. 49, 1052–1060 (2017).

  6. 6.

    et al. Oncotarget 5, 587–598 (2014).

  7. 7.

    , , , & J. Virol. 79, 876–883 (2005).

  8. 8.

    et al. Mol. Cell. Biol. 20, 842–850 (2000).

  9. 9.

    et al. Oncotarget 7, 33484–33497 (2016).

  10. 10.

    , & Mol. Cell 62, 766–776 (2016).

  11. 11.

    & Mobile DNA 7, 24 (2016).

  12. 12.

    , , & Cancer Res. 76, 1683–1689 (2016).

  13. 13.

    et al. Cell 162, 974–986 (2015).

  14. 14.

    et al. Cell 162, 961–973 (2015).

  15. 15.

    et al. J. Virol. 87, 25–36 (2013).

Download references

Author information

Affiliations

  1. Dixie L. Mager and Matthew C. Lorincz are in the Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

    • Dixie L Mager
    •  & Matthew C Lorincz
  2. Dixie L. Mager is also at the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

    • Dixie L Mager

Authors

  1. Search for Dixie L Mager in:

  2. Search for Matthew C Lorincz in:

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Dixie L Mager or Matthew C Lorincz.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ng.3902

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing