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Adenine N6-methylation in diverse fungi

A DNA modification—methylation of cytosines and adenines—has important roles in diverse processes such as regulation of gene expression and genome stability, yet until recently adenine methylation had been considered to be only a hallmark of prokaryotes. A new study identifies abundant adenine methylation of transcriptionally active genes in early-diverging fungi that, together with recent other work, emphasizes the importance of adenine methylation in eukaryotes.

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Figure 1: Adenine N6-methylation in phylogenetically diverse eukaryotes.


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Correspondence to Michael F Seidl.

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Seidl, M. Adenine N6-methylation in diverse fungi. Nat Genet 49, 823–824 (2017).

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