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Innate and adaptive immunity shape circulating HCV strains

An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for infection outcome.

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Figure 1: The host antiviral immune response is a major driver of HCV evolution.


  1. Bartha, I. et al. eLife 2, e01123 (2013).

    Article  Google Scholar 

  2. Ansari, M.A. et al. Nat. Genet. 49, 666–673 (2017).

    Article  CAS  Google Scholar 

  3. Rauch, A., Gaudieri, S., Thio, C. & Bochud, P.Y. Pharmacogenomics 10, 1819–1837 (2009).

    Article  CAS  Google Scholar 

  4. Ge, D. et al. Nature 461, 399–401 (2009).

    Article  CAS  Google Scholar 

  5. Rauch, A. et al. Gastroenterology 138, 1338–1345, 1345.e1–1345.e7 (2010).

    Article  CAS  Google Scholar 

  6. Sheahan, T. et al. Cell Host Microbe 15, 190–202 (2014).

    Article  CAS  Google Scholar 

  7. Moore, C.B. et al. Science 296, 1439–1443 (2002).

    Article  CAS  Google Scholar 

  8. Gaudieri, S. et al. J. Virol. 80, 11094–11104 (2006).

    Article  CAS  Google Scholar 

  9. von Delft, A. et al. Gut 65, 112–123 (2016).

    Article  CAS  Google Scholar 

  10. Erdmann, N. et al. PLoS Pathog. 11, e1005111 (2015).

    Article  Google Scholar 

  11. Ray, S.C. et al. J. Exp. Med. 201, 1753–1759 (2005).

    Article  CAS  Google Scholar 

  12. Carlson, J.M. et al. Nat. Med. 22, 606–613 (2016).

    Article  Google Scholar 

  13. Alter, G. et al. Nature 476, 96–100 (2011).

    Article  CAS  Google Scholar 

  14. Suppiah, V. et al. PLoS Med. 8, e1001092 (2011).

    Article  CAS  Google Scholar 

  15. Fitzmaurice, K. et al. Gut 64, 813–819 (2015).

    Article  CAS  Google Scholar 

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Correspondence to Silvana Gaudieri.

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Gaudieri, S., Lucas, M. Innate and adaptive immunity shape circulating HCV strains. Nat Genet 49, 657–658 (2017).

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