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Untangling the genetics from the epigenetics in pancreatic cancer metastasis

Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

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Figure 1: An epigenomic reprogramming model of pancreatic cancer metastasis.

Marina Corral Spence/Springer Nature

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Correspondence to Christopher R Vakoc or David A Tuveson.

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Vakoc, C., Tuveson, D. Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet 49, 323–324 (2017). https://doi.org/10.1038/ng.3798

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