Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Untangling the genetics from the epigenetics in pancreatic cancer metastasis

Nature Genetics volume 49, pages 323–324 (2017)Cite this article

Subjects

Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: An epigenomic reprogramming model of pancreatic cancer metastasis.

Marina Corral Spence/Springer Nature

References

  1. Garraway, L.A. & Lander, E.S. Cell 153, 17–37 (2013).

    Article  CAS  Google Scholar 

  2. Stratton, M.R., Campbell, P.J. & Futreal, P.A. Nature 458, 719–724 (2009).

    Article  CAS  Google Scholar 

  3. Gibson, W.J. et al. Nat. Genet. 48, 848–855 (2016).

    Article  CAS  Google Scholar 

  4. Sanborn, J.Z. et al. Proc. Natl. Acad. Sci. USA 112, 10995–11000 (2015).

    Article  CAS  Google Scholar 

  5. Gundem, G. et al. Nature 520, 353–357 (2015).

    Article  CAS  Google Scholar 

  6. Campbell, P.J. et al. Nature 467, 1109–1113 (2010).

    Article  CAS  Google Scholar 

  7. Yachida, S. et al. Nature 467, 1114–1117 (2010).

    Article  CAS  Google Scholar 

  8. Vanharanta, S. & Massagué, J. Cancer Cell 24, 410–421 (2013).

    Article  CAS  Google Scholar 

  9. McDonald, O.G. et al. Nat. Genet. 49, 358–366 (2017).

    Article  Google Scholar 

  10. Makohon-Moore, A.P. et al. Nat. Genet. 49, 367–376 (2017).

    Article  Google Scholar 

  11. Tam, W.L. & Weinberg, R.A. Nat. Med. 19, 1438–1449 (2013).

    Article  CAS  Google Scholar 

  12. Denny, S.K. et al. Cell 166, 328–342 (2016).

    Article  CAS  Google Scholar 

  13. Feinberg, A.P., Ohlsson, R. & Henikoff, S. Nat. Rev. Genet. 7, 21–33 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Christopher R. Vakoc and David A. Tuveson are at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.,

    Christopher R Vakoc & David A Tuveson

Authors
  1. Christopher R Vakoc
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A Tuveson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Christopher R Vakoc or David A Tuveson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vakoc, C., Tuveson, D. Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet 49, 323–324 (2017). https://doi.org/10.1038/ng.3798

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3798

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer