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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Nature Genetics volume 49, pages 1767–1778 (2017)Cite this article

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Abstract

Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease1. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10−8 with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.

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Figure 1: Genomic region around the independent ER-negative risk-associated variants 11_108345515_G_A (rs11374964) and 11_108357137_G_A (rs74911261).

References

  1. Michailidou, K. et al. Association analysis identifies 65 new breast cancer risk loci. Nature (in press).

  2. Ahmed, S. et al. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat. Genet. 41, 585–590 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Antoniou, A.C. et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nat. Genet. 42, 885–892 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cai, Q. et al. Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium. Hum. Mol. Genet. 20, 4991–4999 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cox, A. et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat. Genet. 39, 352–358 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Easton, D.F. et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087–1093 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Fletcher, O. et al. Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. J. Natl. Cancer Inst. 103, 425–435 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Ghoussaini, M. et al. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat. Genet. 44, 312–318 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Haiman, C.A. et al. A common variant at the TERT–CLPTM1L locus is associated with estrogen receptor–negative breast cancer. Nat. Genet. 43, 1210–1214 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Hein, R. et al. Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association Consortium (BCAC). PLoS One 7, e42380 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hunter, D.J. et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet. 39, 870–874 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Siddiq, A. et al. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum. Mol. Genet. 21, 5373–5384 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Stacey, S.N. et al. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer. Nat. Genet. 39, 865–869 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. Stacey, S.N. et al. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer. Nat. Genet. 40, 703–706 (2008).

    Article  CAS  PubMed  Google Scholar 

  15. Thomas, G. et al. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat. Genet. 41, 579–584 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Turnbull, C. et al. Genome-wide association study identifies five new breast cancer susceptibility loci. Nat. Genet. 42, 504–507 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Zheng, W. et al. Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat. Genet. 41, 324–328 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Bojesen, S.E. et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat. Genet. 45, 371–384, e1–e2 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Garcia-Closas, M. et al. Genome-wide association studies identify four ER negative–specific breast cancer risk loci. Nat. Genet. 45, 392–398, e1–e2 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Michailidou, K. et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat. Genet. 45, 353–361, e1–e2 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Cai, Q. et al. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nat. Genet. 46, 886–890 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Long, J. et al. Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet. 8, e1002532 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Michailidou, K. et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat. Genet. 47, 373–380 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Milne, R.L. et al. Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. Hum. Mol. Genet. 23, 6096–6111 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Gaudet, M.M. et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet. 9, e1003173 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Meyer, K.B. et al. Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am. J. Hum. Genet. 93, 1046–1060 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Orr, N. et al. Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. Hum. Mol. Genet. 24, 2966–2984 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. French, J.D. et al. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am. J. Hum. Genet. 92, 489–503 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Dunning, A.M. et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat. Genet. 48, 374–386 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Couch, F.J. et al. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nat. Commun. 7, 11375 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Lawrenson, K. et al. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus. Nat. Commun. 7, 12675 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  32. Wyszynski, A. et al. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum. Mol. Genet. 25, 3863–3876 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Mavaddat, N. et al. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol. Biomarkers Prev. 21, 134–147 (2012).

    Article  CAS  PubMed  Google Scholar 

  34. Amos, C.I. et al. The OncoArray Consortium: a network for understanding the genetic architecture of common cancers. Cancer Epidemiol. Biomarkers Prev. 26, 126–135 (2017).

    Article  PubMed  Google Scholar 

  35. Antoniou, A.C. et al. A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet. Epidemiol. 29, 1–11 (2005).

    Article  PubMed  Google Scholar 

  36. Barnes, D.R., Lee, A., Easton, D.F. & Antoniou, A.C. Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations. Genet. Epidemiol. 36, 274–291 (2012).

    Article  PubMed  Google Scholar 

  37. Ahsan, H. et al. A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Cancer Epidemiol. Biomarkers Prev. 23, 658–669 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Stevens, K.N. et al. 19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res. 72, 1795–1803 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Willer, C.J., Li, Y. & Abecasis, G.R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Maller, J.B. et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet. 44, 1294–1301 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Udler, M.S., Tyrer, J. & Easton, D.F. Evaluating the power to discriminate between highly correlated SNPs in genetic association studies. Genet. Epidemiol. 34, 463–468 (2010).

    Article  PubMed  Google Scholar 

  42. ENCODE Project Consortium. A user's guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol. 9, e1001046 (2011).

  43. Kheradpour, P. & Kellis, M. Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments. Nucleic Acids Res. 42, 2976–2987 (2014).

    Article  CAS  PubMed  Google Scholar 

  44. Kundaje, A. et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317–330 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Boyle, A.P. et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22, 1790–1797 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. He, B., Chen, C., Teng, L. & Tan, K. Global view of enhancer–promoter interactome in human cells. Proc. Natl. Acad. Sci. USA 111, E2191–E2199 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Rao, S.S. et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665–1680 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Corradin, O. et al. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Genome Res. 24, 1–13 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Forrest, A.R. et al. A promoter-level mammalian expression atlas. Nature 507, 462–470 (2014).

    Article  CAS  PubMed  Google Scholar 

  50. GTEx Consortium. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648–660 (2015).

  51. Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934–947 (2013).

    Article  CAS  PubMed  Google Scholar 

  52. Westra, H.J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238–1243 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. James, L.I. et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J. Med. Chem. 56, 7358–7371 (2013).

    Article  CAS  PubMed  Google Scholar 

  54. Sukari, A., Muqbil, I., Mohammad, R.M., Philip, P.A. & Azmi, A.S. F-BOX proteins in cancer cachexia and muscle wasting: emerging regulators and therapeutic opportunities. Semin. Cancer Biol. 36, 95–104 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Ling Zheng, L. et al. Interaction of heat shock protein Cpn10 with the cyclin E/Cdk2 substrate nuclear protein ataxia-telangiectasia (NPAT) is involved in regulating histone transcription. J. Biol. Chem. 290, 29290–29300 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  56. Easton, D.F. et al. Gene-panel sequencing and the prediction of breast-cancer risk. N. Engl. J. Med. 372, 2243–2257 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Rogers, S. et al. Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells. Cell Div. 10, 1 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  58. Li, Q. et al. Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell 152, 633–641 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61–70 (2012).

  60. Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486, 346–352 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Merico, D., Isserlin, R., Stueker, O., Emili, A. & Bader, G.D. Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One 5, e13984 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  62. Wang, K., Li, M. & Bucan, M. Pathway-based approaches for analysis of genomewide association studies. Am. J. Hum. Genet. 81, 1278–1283 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Wang, K., Li, M. & Hakonarson, H. Analysing biological pathways in genome-wide association studies. Nat. Rev. Genet. 11, 843–854 (2010).

    Article  CAS  PubMed  Google Scholar 

  64. Wang, L., Jia, P., Wolfinger, R.D., Chen, X. & Zhao, Z. Gene set analysis of genome-wide association studies: methodological issues and perspectives. Genomics 98, 1–8 (2011).

    Article  CAS  PubMed  Google Scholar 

  65. Hacker, B.M. et al. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). Genomics 50, 97–104 (1998).

    Article  CAS  PubMed  Google Scholar 

  66. Melhem-Bertrandt, A. et al. β-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J. Clin. Oncol. 29, 2645–2652 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Pon, C.K., Lane, J.R., Sloan, E.K. & Halls, M.L. The β2-adrenoceptor activates a positive cAMP–calcium feedforward loop to drive breast cancer cell invasion. FASEB J. 30, 1144–1154 (2016).

    Article  CAS  PubMed  Google Scholar 

  68. Finucane, H.K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228–1235 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236–1241 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Bulik-Sullivan, B.K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291–295 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Milne, R.L. & Antoniou, A.C. Genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers. Ann. Oncol. 22 (Suppl. 1), i11–i17 (2011).

    Article  PubMed  Google Scholar 

  72. Mavaddat, N. et al. Prediction of breast cancer risk based on profiling with common genetic variants. J. Natl. Cancer Inst. 107, djv036 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  73. Delaneau, O., Marchini, J. & Zagury, J.F. A linear complexity phasing method for thousands of genomes. Nat. Methods 9, 179–181 (2011).

    Article  PubMed  CAS  Google Scholar 

  74. Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  75. Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. & Abecasis, G.R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet. 44, 955–959 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Li, Y., Willer, C.J., Ding, J., Scheet, P. & Abecasis, G.R. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet. Epidemiol. 34, 816–834 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  77. Aulchenko, Y.S., Struchalin, M.V. & van Duijn, C.M. ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics 11, 134 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  78. Antoniou, A.C. & Easton, D.F. Polygenic inheritance of breast cancer: implications for design of association studies. Genet. Epidemiol. 25, 190–202 (2003).

    Article  PubMed  Google Scholar 

  79. Antoniou, A.C. et al. The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions. Br. J. Cancer 98, 1457–1466 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Darabi, H. et al. Polymorphisms in a putative enhancer at the 10q21.2 breast cancer risk locus regulate NRBF2 expression. Am. J. Hum. Genet. 97, 22–34 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Glubb, D.M. et al. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am. J. Hum. Genet. 96, 5–20 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Ghoussaini, M. et al. Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat. Commun. 4, 4999 (2014).

    Article  PubMed  CAS  Google Scholar 

  83. Baran, Y. et al. Fast and accurate inference of local ancestry in Latino populations. Bioinformatics 28, 1359–1367 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Abecasis, G.R. et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56–65 (2012).

    Article  PubMed  CAS  Google Scholar 

  85. Li, B. & Dewey, C.N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Mermel, C.H. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  87. Shabalin, A.A. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics 28, 1353–1358 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498–2504 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out.

Genotyping for the OncoArray was funded by the government of Canada through Genome Canada and the Canadian Institutes of Health Research (GPH-129344), the Ministère de l'Économie, de la Science et de l'Innovation du Québec through Génome Québec, the Quebec Breast Cancer Foundation for the PERSPECTIVE project, the US National Institutes of Health (NIH) (1 U19 CA 148065 for the Discovery, Biology and Risk of Inherited Variants in Breast Cancer (DRIVE) project and X01HG007492 to the Center for Inherited Disease Research (CIDR) under contract HHSN268201200008I), Cancer Research UK (C1287/A16563), the Odense University Hospital Research Foundation (Denmark), the National R&D Program for Cancer Control–Ministry of Health and Welfare (Republic of Korea) (1420190), the Italian Association for Cancer Research (AIRC; IG16933), the Breast Cancer Research Foundation, the National Health and Medical Research Council (Australia) and German Cancer Aid (110837).

Genotyping for the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710, C1287/A10118 and C12292/A11174]), NIH grants (CA128978, CA116167 and CA176785) and the Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 (GAME-ON initiative)), an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, the Ministère de l'Économie, Innovation et Exportation du Québec (PSR-SIIRI-701), the Komen Foundation for the Cure, the Breast Cancer Research Foundation and the Ovarian Cancer Research Fund.

Combination of the GWAS data was supported in part by the NIH Cancer Post-Cancer GWAS initiative (1 U19 CA 148065) (DRIVE, part of the GAME-ON initiative). LD score regression analysis was supported by grant CA194393.

BCAC is funded by Cancer Research UK (C1287/A16563) and by the European Union via its Seventh Framework Programme (HEALTH-F2-2009-223175, COGS) and the Horizon 2020 Research and Innovation Programme (633784, B-CAST; 634935, BRIDGES). CIMBA is funded by Cancer Research UK (C12292/A20861 and C12292/A11174).

For a full description of funding and acknowledgments, see the Supplementary Note.

Author information

Author notes

  1. Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou and Marjanka K Schmidt: These authors contributed equally to this work.

  2. Gary D Bader, Paul D P Pharoah, Fergus J Couch, Douglas F Easton, Peter Kraft, Georgia Chenevix-Trench, Montserrat García-Closas, Marjanka K Schmidt, Antonis C Antoniou and Jacques Simard: These authors jointly directed this work.

Authors and Affiliations

  1. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia

    Roger L Milne, Pierre-Antoine Dugué, Graham G Giles & Robert J MacInnis

  2. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia

    Roger L Milne, Pierre-Antoine Dugué, Graham G Giles, John L Hopper, Robert J MacInnis, Enes Makalic & Daniel F Schmidt

  3. Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK

    Karoline B Kuchenbaecker, Kyriaki Michailidou, Joe Dennis, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Jamie Allen, Daniel Barnes, Daniel Barrowdale, Debra Frost, Julie Lecarpentier, Andrew Lee, Michael Lush, Paul D P Pharoah, Douglas F Easton & Antonis C Antoniou

  4. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK

    Karoline B Kuchenbaecker

  5. Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus

    Kyriaki Michailidou

  6. Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

    Jonathan Beesley, Xiaoqing Chen, Amanda B Spurdle & Georgia Chenevix-Trench

  7. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK

    Siddhartha Kar, Shahana Ahmed, Caroline Baynes, Don M Conroy, Ed Dicks, Alison M Dunning, Laura Fachal, Patricia Harrington, Catherine S Healey, Craig Luccarini, Valerie Rhenius, Mitul Shah, Jonathan Tyrer, Paul D P Pharoah & Douglas F Easton

  8. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA

    Sara Lindström

  9. Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

    Sara Lindström, Xia Jiang, Hilary Finucane, David J Hunter, Rulla M Tamimi & Peter Kraft

  10. Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

    Shirley Hui, Asha Rostamianfar & Gary D Bader

  11. Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada

    Audrey Lemaçon, Penny Soucy, Stéphane Dubois, Martine Dumont, Martine Tranchant, Arnaud Droit & Jacques Simard

  12. Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Hilary Finucane

  13. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands

    Cora M Aalfs & Hanne Meijers-Heijboer

  14. Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Marcia Adams, Kimberly F Doheny, Elizabeth Pugh & Jane Romm

  15. Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK

    Julian Adlard

  16. Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS, Padua, Italy

    Simona Agata & Marco Montagna

  17. Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA

    Habibul Ahsan & Ling Tong

  18. Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

    Kristiina Aittomäki

  19. Personalised Medicine Team, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

    Fares Al-Ejeh

  20. Roswell Park Cancer Institute, Buffalo, New York, USA

    Christine B Ambrosone

  21. Department of Biomedical Data Science, Center for Genomic Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA

    Christopher I Amos & Jinyoung Byun

  22. Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada

    Irene L Andrulis & Gord Glendon

  23. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    Irene L Andrulis

  24. Department of Epidemiology, University of California, Irvine, Irvine, California, USA

    Hoda Anton-Culver & Argyrios Ziogas

  25. N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus

    Natalia N Antonenkova & Natalia V Bogdanova

  26. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Volker Arndt, Hermann Brenner & Katarina Cuk

  27. Institute of Clinical Molecular Biology / Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany

    Norbert Arnold

  28. Department of Public Health Sciences and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada

    Kristan J Aronson

  29. Institute of Human Genetics, Hannover Medical School, Hannover, Germany

    Bernd Auber

  30. Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    Paul L Auer & Ross Prentice

  31. Zilber School of Public Health, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, USA

    Paul L Auer

  32. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

    Margreet G E M Ausems

  33. Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy

    Jacopo Azzollini, Siranoush Manoukian, Bernard Peissel & Daniela Zaffaroni

  34. McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada

    François Bacot, Nathalie Hamel, Daniel C Tessier & Daniel Vincent

  35. Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain

    Judith Balmaña

  36. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy

    Monica Barile & Bernardo Bonanni

  37. Bâtiment Cheney D, Centre Léon Bérard, Lyon, France

    Laure Barjhoux & Francesca Damiola

  38. Department of Pathology, Laboratory of Cell Biology, Landspitali, Reykjavik, Iceland

    Rosa B Barkardottir

  39. BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland

    Rosa B Barkardottir

  40. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Myrto Barrdahl, Jenny Chang-Claude, Ursula Eilber, Rudolf Kaaks & Anja Rudolph

  41. Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

    Matthias W Beckmann, Peter A Fasching, Lothar Haeberle & Alexander Hein

  42. Human Genotyping Unit -Centro Nacional de Genotipado (CEGEN), Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO),, Madrid, Spain

    Javier Benitez & Anna González-Neira

  43. Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain

    Javier Benitez & Ana Osorio

  44. Spanish Network on Rare Diseases (CIBERER), Madrid, Spain

    Javier Benitez & Ana Osorio

  45. Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation

    Marina Bermisheva & Elza Khusnutdinova

  46. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA

    Leslie Bernstein, Yuan Chun Ding & Susan L Neuhausen

  47. Université Clermont Auvergne, INSERM, U1240, Imagerie Moléculaire et Stratégies Théranostiques, Centre Jean Perrin, Clermont-Ferrand, France

    Yves-Jean Bignon

  48. Clinical Cancer Genetics, City of Hope, Duarte, California, USA

    Kathleen R Blazer & Jeffrey N Weitzel

  49. Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands

    Marinus J Blok

  50. Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

    Carl Blomqvist

  51. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    William Blot, Qiuyin Cai, Jirong Long, Martha J Shrubsole, Xiao-Ou Shu & Wei Zheng

  52. International Epidemiology Institute, Rockville, Maryland, USA

    William Blot

  53. City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA

    Kristie Bobolis & Sue Nadesan

  54. Vesalius Research Center, VIB, Leuven, Belgium

    Bram Boeckx & Diether Lambrechts

  55. Department of Oncology, Laboratory for Translational Genetics, University of Leuven, Leuven, Belgium

    Bram Boeckx & Diether Lambrechts

  56. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

    Natalia V Bogdanova & Hans Christiansen

  57. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

    Natalia V Bogdanova, Thilo Dörk, Sonja Helbig, Peter Hillemanns, Tjoung-Won Park-Simon & Peter Schürmann

  58. Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark

    Anders Bojesen

  59. Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

    Stig E Bojesen, Sune F Nielsen & Børge G Nordestgaard

  60. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

    Stig E Bojesen, Sune F Nielsen & Børge G Nordestgaard

  61. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Stig E Bojesen & Børge G Nordestgaard

  62. Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway

    Anne-Lise Børresen-Dale, Grethe I Grenaker Alnæs & Vessela N Kristensen

  63. Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary

    Aniko Bozsik & Edith Olah

  64. Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Angela R Bradbury, Susan M Domchek & Katherine L Nathanson

  65. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Judith S Brand, Kamila Czene, Hatef Darabi, Mikael Eriksson, Marike Gabrielson, Keith Humphreys, Jingmei Li & Per Hall

  66. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

    Hiltrud Brauch & Wing-Yee Lo

  67. University of Tübingen, Tübingen, Germany

    Hiltrud Brauch & Wing-Yee Lo

  68. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Hiltrud Brauch & Hermann Brenner

  69. Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany

    Hermann Brenner

  70. Biopathology Department, Gustave Roussy, Villejuif, France

    Brigitte Bressac-de Paillerets & Olivier Caron

  71. Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK

    Carole Brewer

  72. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA

    Louise Brinton, Stephen J Chanock, Jonine Figueroa, Bob Hoover, Zhaoming Wang, Xiaohong R Yang & Montserrat García-Closas

  73. Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden

    Per Broberg & Håkan Olsson

  74. Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada

    Angela Brooks-Wilson

  75. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada

    Angela Brooks-Wilson

  76. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain

    Joan Brunet

  77. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany

    Thomas Brüning

  78. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

    Barbara Burwinkel & Harald Surowy

  79. Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Barbara Burwinkel & Harald Surowy

  80. Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA

    Saundra S Buys

  81. Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain

    Trinidad Caldés, Vanesa Garcia-Barberan, José A García-Sáenz & Atocha Romero

  82. Department of Laboratory Medicine, Section of Molecular Genetics, University of Pisa and University Hospital of Pisa, Pisa, Italy

    Maria A Caligo

  83. Research Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

    Ian Campbell

  84. Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia

    Ian Campbell, Paul James & Gillian Mitchell

  85. Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Federico Canzian

  86. Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servizo Galego de Saúde SERGAS, Santiago de Compostela, Spain

    Angel Carracedo & Manuela Gago-Dominguez

  87. Centro de Investigación en Red de Enfermedades Raras (CIBERER) and Centro Nacional de Genotipado (CEGEN-PRB2), Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    Angel Carracedo

  88. Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA

    Brian D Carter, Susan M Gapstur & Mia M Gaudet

  89. Oncology and Genetics Unit, Instituto de Investigación Biomédica (IBI) de Orense-Pontevedra-Vigo, Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde SERGAS, Vigo, Spain

    J Esteban Castelao

  90. Centre François Baclesse, Caen, France

    Laurent Castera

  91. Service de Génétique Oncologique and INSERM U830, Institut Curie, Paris, France - Université Paris Descartes, Sorbonne Paris Cité,

    Virginie Caux-Moncoutier, Marion Gauthier-Villars & Dominique Stoppa-Lyonnet

  92. Cancer Genetics and Prevention Program, University of California, San Francisco, San Francisco, California, USA

    Salina B Chan

  93. University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Jenny Chang-Claude

  94. Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA

    Ting-Yuan David Cheng

  95. Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec City, Québec, Canada

    Jocelyne Chiquette

  96. Center for Medical Genetics, Ghent University, Ghent, Belgium

    Kathleen B M Claes, Kim De Leeneer & Bruce Poppe

  97. Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia

    Christine L Clarke

  98. Huntsman Cancer Institute, Salt Lake City, Utah, USA

    Thomas Conner

  99. Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK

    Jackie Cook

  100. Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France

    Emilie Cordina-Duverger, Pascal Guénel & Thérèse Truong

  101. Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Sten Cornelissen, Renske Keeman, Jelle Wesseling & Marjanka K Schmidt

  102. Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France

    Isabelle Coupier

  103. Department of Oncology and Metabolism, Academic Unit of Molecular Oncology, University of Sheffield, Sheffield, UK

    Angela Cox

  104. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

    David G Cox

  105. INSERM U1052, Cancer Research Center of Lyon, Lyon, France

    David G Cox

  106. Department of Neuroscience, Academic Unit of Pathology, University of Sheffield, Sheffield, UK

    Simon S Cross

  107. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

    Julie M Cunningham, Chunling Hu, Jeffery Meyer, Hermela Shimelis, Jason Vollenweider & Fergus J Couch

  108. Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Mary B Daly

  109. Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK

    Rosemarie Davidson

  110. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

    Peter Devilee

  111. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

    Peter Devilee & Juul T Wijnen

  112. Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Barcelona, Spain

    Orland Diez

  113. Department of Gynecology and Obstetrics, Ludwig Maximilians University of Munich, Munich, Germany

    Nina Ditsch & Brigitte Rack

  114. Department of Genetics, Cancer Genetics Laboratory, University of Pretoria, Arcadia, South Africa

    Cecilia M Dorfling & Elizabeth J van Rensburg

  115. Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

    Isabel dos-Santos-Silva & Julian Peto

  116. Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK

    Lorraine Durcan & Tom Maishman

  117. Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK

    Lorraine Durcan, Diana Eccles & Tom Maishman

  118. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK

    Miriam Dwek & Nadege Presneau

  119. Institute of Human Genetics, University of Münster, Münster, Germany

    Bernd Dworniczak

  120. Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK

    Ros Eeles

  121. Department of Clinical Genetics, Lund University Hospital, Lund, Sweden

    Hans Ehrencrona

  122. Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    Bent Ejlertsen

  123. Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

    Arif B Ekici

  124. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    A Heather Eliassen & Rulla M Tamimi

  125. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

    A Heather Eliassen, David J Hunter, Rulla M Tamimi, Walter Willett & Peter Kraft

  126. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

    Christoph Engel

  127. LIFE–Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany

    Christoph Engel

  128. Genetics Department, Dijon University Hospital, Dijon, France

    Laurence Faivre

  129. Oncogenetics, Centre Georges-François Leclerc, Dijon, France

    Laurence Faivre

  130. Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

    Peter A Fasching

  131. Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany

    Ulrike Faust

  132. Usher Institute of Population Health Sciences and Informatics, CRUK Edinburgh Centre, University of Edinburgh Medical School, Edinburgh, UK

    Jonine Figueroa

  133. Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Dieter Flesch-Janys

  134. Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Dieter Flesch-Janys & Kathrin Thöne

  135. Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK

    Olivia Fletcher, Nichola Johnson & Nick Orr

  136. Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

    Henrik Flyger

  137. Departments of Human Genetics and Oncology, Program in Cancer Genetics, McGill University, Montréal, Québec, Canada

    William D Foulkes & Marc Tischkowitz

  138. Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel

    Eitan Friedman & Yael Laitman

  139. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

    Eitan Friedman

  140. School of Public Health, Curtin University, Perth, Western Australia, Australia

    Lin Fritschi

  141. Clinical Cancer Genetics Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Pragna Gaddam

  142. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    Marilie D Gammon

  143. Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Schools of Medicine and Public Health, University of California, Los Angeles, Los Angeles, California, USA

    Patricia A Ganz

  144. Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Judy Garber

  145. Department of Medical Genetics, Centre of Familial Breast and Ovarian Cancer, Institute of Human Genetics, University Würzburg, Würzburg, Germany

    Andrea Gehrig

  146. Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece

    Vassilios Georgoulias & Dimitrios Mavroudis

  147. Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark

    Anne-Marie Gerdes

  148. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

    Andrew K Godwin

  149. Department of Medicine, McGill University, Montréal, Québec, Canada

    Mark S Goldberg

  150. Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, Québec, Canada

    Mark S Goldberg

  151. Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA

    David E Goldgar

  152. Department of Obstetrics and Gynecology, Ohio State University James Comprehensive Cancer Center, Columbus, Ohio, USA

    Paul Goodfellow

  153. Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA

    Mark H Greene & Jennifer T Loud

  154. Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland

    Mervi Grip

  155. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

    Jacek Gronwald, Anna Jakubowska, Katarzyna Kaczmarek, Jan Lubinski & Grzegorz Sukiennicki

  156. Centre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Montréal, Québec, Canada

    Anne Grundy

  157. Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria

    Daphne Gschwantler-Kaulich, Sung-Won Kim, Christine Rappaport-Fuerhauser, Christian F Singer & Yen Y Tan

  158. Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK

    Qi Guo & Georg Pfeiler

  159. Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany

    Eric Hahnen, Kerstin Rhiem, Barbara Wappenschmidt & Rita K Schmutzler

  160. Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany

    Eric Hahnen, Kerstin Rhiem & Barbara Wappenschmidt

  161. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

    Eric Hahnen, Kerstin Rhiem, Barbara Wappenschmidt & Rita K Schmutzler

  162. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

    Christopher A Haiman, Eunjung Lee, Xin Sheng, David Van Den Berg, Anna H Wu & Lucy Xia

  163. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Niclas Håkansson & Alicja Wolk

  164. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA

    Emily Hallberg, Steven N Hart, Aaron Norman, Janet E Olson, Curtis Olswold, Christopher Scott & Celine Vachon

  165. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Ute Hamann, Guanmengqian Huang, Maria Kabisch & Diana Torres

  166. Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA

    Susan Hankinson

  167. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    Thomas V O Hansen

  168. Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland

    Jaana M Hartikainen, Veli-Matti Kosma, Maria Tengström & Arto Mannermaa

  169. Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

    Jaana M Hartikainen, Veli-Matti Kosma & Arto Mannermaa

  170. Department of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, Finland

    Jaana M Hartikainen, Veli-Matti Kosma & Arto Mannermaa

  171. Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK

    Alex Henderson

  172. School of Population Health, University of Western Australia, Perth, Western Australia, Australia

    Jane Heyworth

  173. Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory (CGR), National Cancer Institute, Bethesda, Maryland, USA

    Belynda Hicks, Kristine Jones & Bin Zhu

  174. Medical Genetics Unit, St George's, University of London, London, UK

    Shirley Hodgson

  175. Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Frans B Hogervorst

  176. Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

    Antoinette Hollestelle, Maartje J Hooning, John W M Martens & Caroline Seynaeve

  177. Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois, USA

    Peter J Hulick

  178. Pritzker School of Medicine, University of Chicago, Evanston, Illinois, USA

    Peter J Hulick

  179. N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation

    Evgeny N Imyanitov

  180. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA

    Claudine Isaacs

  181. Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan

    Motoki Iwasaki

  182. Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK

    Louise Izatt

  183. Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Paul James & Gillian Mitchell

  184. State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

    Ramunas Janavicius

  185. Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany

    Wolfgang Janni, Brigitte Rack, Lukas Schwentner & Shan Wang-Gohrke

  186. Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark

    Uffe Birk Jensen

  187. Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA

    Esther M John

  188. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA

    Esther M John & Alice S Whittemore

  189. Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK

    Michael Jones, Minouk J Schoemaker & Anthony Swerdlow

  190. Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland

    Arja Jukkola-Vuorinen

  191. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Daehee Kang & Sue K Park

  192. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea

    Daehee Kang

  193. Cancer Research Institute, Seoul National University, Seoul, Republic of Korea

    Daehee Kang & Sue K Park

  194. Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

    Karin Kast

  195. School of Medicine, National University of Ireland, Galway, Ireland

    Michael J Kerin & Nicola Miller

  196. Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Carolien M Kets

  197. Department of Oncology, Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

    Machteld Keupers & Ines Nevelsteen

  198. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

    Sofia Khan, Johanna I Kiiski & Heli Nevanlinna

  199. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation

    Elza Khusnutdinova & Darya Prokofieva

  200. Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada

    Julia A Knight

  201. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

    Julia A Knight

  202. Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece

    Irene Konstantopoulou & Drakoulis Yannoukakos

  203. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

    Vessela N Kristensen

  204. Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway

    Vessela N Kristensen

  205. Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

    Torben A Kruse & Mads Thomassen

  206. Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong

    Ava Kwong

  207. Department of Surgery, University of Hong Kong, Hong Kong

    Ava Kwong

  208. Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong

    Ava Kwong

  209. Department of Pathology, Division Slagelse, University Hospital of Region Zealand, Slagelse, Denmark

    Anne-Vibeke Lænkholm

  210. Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK

    Fiona Lalloo

  211. Clalit National Cancer Control Center, Haifa, Israel

    Keren Landsman, Flavio Lejbkowicz, Mila Pinchev, Gad Rennert & Hedy S Rennert

  212. Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France

    Christine Lasset

  213. Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain

    Conxi Lazaro

  214. University of Hawaii Cancer Center, Honolulu, Hawaii, USA

    Loic Le Marchand

  215. Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

    Jong Won Lee

  216. Department of Surgery, Soonchunhyang University and Hospital, Seoul, Republic of Korea

    Min Hyuk Lee

  217. Institut Curie, Paris, France

    Fabienne Lesueur

  218. PSL Research University, Paris, France

    Fabienne Lesueur

  219. INSERM U900, Paris, France

    Fabienne Lesueur

  220. Mines Paris Tech, Fontainebleau, France

    Fabienne Lesueur

  221. Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona, USA

    Jenna Lilyquist

  222. Department of Medicine, Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Anne Lincoln & Joseph Vijai

  223. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    Annika Lindblom

  224. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland

    Jolanta Lissowska

  225. German Breast Group, Neu Isenburg, Germany

    Sibylle Loibl

  226. Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Macedonia

    Ivana Maleva Kostovska & Dijana Plaseska-Karanfilska

  227. Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    Kathleen E Malone

  228. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    JoAnn E Manson

  229. Department of Oncology, Pathology, Karolinska Institutet, Stockholm, Sweden

    Sara Margolin & Camilla Wendt

  230. Moores Cancer Center, University of California, San Diego, La Jolla, California, USA

    Maria Elena Martinez & Manuela Gago-Dominguez

  231. Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, USA

    Maria Elena Martinez

  232. Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan

    Keitaro Matsuo

  233. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Keitaro Matsuo

  234. Lyon Neuroscience Research Center–CRNL, INSERM U1028, CNRS UMR 5292, University of Lyon, Lyon, France

    Sylvie Mazoyer

  235. Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia

    Catriona McLean

  236. Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

    Hanne Meijers-Heijboer

  237. Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain

    Primitiva Menéndez

  238. Saw Swee Hock School of Public Health, National University of Singapore, Singapore

    Hui Miao

  239. NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA

    Austin Miller

  240. Institute of Population Health, University of Manchester, Manchester, UK

    Kenneth Muir

  241. Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK

    Kenneth Muir

  242. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

    Anna Marie Mulligan

  243. Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada

    Anna Marie Mulligan

  244. Université Paris Sorbonne Cité, INSERM UMRS 1147, Paris, France

    Claire Mulot

  245. Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

    Dieter Niederacher

  246. Department of Medicine, University of California, San Francisco, San Francisco, California, USA

    Robert L Nussbaum

  247. Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois, USA

    Olufunmilayo I Olopade

  248. West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK

    Kai-ren Ong

  249. Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Jan C Oosterwijk

  250. University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, USA

    V Shane Pankratz

  251. Department of Biomedical, Unit of Medical Genetics, Experimental and Clinical Sciences, University of Florence, Florence, Italy

    Laura Papi

  252. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

    Ylva Paulsson-Karlsson

  253. Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Western Australia, Australia

    Rachel Lloyd & Jennifer Stone

  254. Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

    Inge Søkilde Pedersen

  255. Department of Genetics, Portuguese Oncology Institute, Porto, Portugal

    Ana Peixoto & Manuel R Teixeira

  256. Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain

    Jose I A Perez

  257. IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy

    Paolo Peterlongo

  258. Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA

    Catherine M Phelan

  259. South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK

    Mary E Porteous

  260. ProCURE, Catalan Institute of Oncology, IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain

    Miquel Angel Pujana

  261. Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland

    Katri Pylkäs & Robert Winqvist

  262. Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland

    Katri Pylkäs & Robert Winqvist

  263. Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy

    Paolo Radice

  264. Section of Cancer Genetics, The Institute of Cancer Research, London, UK

    Nazneen Rahman & Sheila Seal

  265. Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

    Johanna Rantala

  266. Carmel Medical Center and B. Rappaport Faculty of Medicine-Technion, Haifa, Israel

    Gad Rennert & Hedy S Rennert

  267. Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Andrea Richardson

  268. Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA

    Gustavo C Rodriguez

  269. Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain

    Atocha Romero

  270. Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands

    Matti A Rookus

  271. Institute of Pathology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany

    Thomas Ruediger

  272. Hereditary Cancer Clinic, University Hospital of Heraklion, Heraklion, Greece

    Emmanouil Saloustros

  273. Department of Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Joyce Sanders & Jelle Wesseling

  274. Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA

    Dale P Sandler & Jack A Taylor

  275. National Cancer Institute, Bangkok, Thailand

    Suleeporn Sangrajrang

  276. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA

    Elinor J Sawyer

  277. Research Oncology, Guy's Hospital, King's College London, London, UK

    Fredrick Schumacher

  278. Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia

    Rodney J Scott

  279. Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia

    Rodney J Scott

  280. Division of Human Genetics, Department of Internal Medicine, Clinical Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA

    Leigha Senter

  281. Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

    Priyanka Sharma

  282. School of Public Health, China Medical University, Taichung, Taiwan

    Chen-Yang Shen

  283. Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

    Chen-Yang Shen

  284. North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK

    Lucy E Side

  285. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany

    Christof Sohn

  286. Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia

    Melissa C Southey

  287. Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada

    John J Spinelli

  288. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada

    John J Spinelli

  289. Saarland Cancer Registry, Saarbrücken, Germany

    Christa Stegmaier

  290. Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany

    Christian Sutter

  291. Division of Breast Cancer Research, The Institute of Cancer Research, London, UK

    Anthony Swerdlow

  292. National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA

    Csilla I Szabo

  293. Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA

    Jack A Taylor

  294. Molecular Genetics Laboratory, Clinical Genetics Service, Cruces University Hospital and BioCruces Health Research Institute, Barakaldo, Spain

    Maria-Isabel Tejada

  295. Cancer Center, Kuopio University Hospital, Kuopio, Finland

    Maria Tengström

  296. Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland

    Maria Tengström

  297. Cancer Research Malaysia, Subang Jaya, Malaysia

    Soo H Teo

  298. Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia

    Soo H Teo

  299. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA

    Mary B Terry

  300. Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain

    Alex Teulé

  301. Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Darcy L Thull

  302. Ospedale di Circolo ASST Settelaghi, Varese, Italy

    Maria Grazia Tibiletti & Kristin K Zorn

  303. Latvian Biomedical Research and Study Centre, Riga, Latvia

    Laima Tihomirova

  304. Department of Medical Genetics, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, UK

    Marc Tischkowitz

  305. Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA

    Amanda E Toland

  306. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

    Rob A E M Tollenaar

  307. Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK

    Ian Tomlinson

  308. Institute of Human Genetics, Pontificia Universidad Javeriana, Bogotá, Colombia

    Diana Torres

  309. Department of Medical Oncology, Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, New South Wales, Australia

    Kathy Tucker

  310. Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

    Nadine Tung

  311. Frauenklinik der Stadtklinik Baden Baden, Baden Baden, Germany

    Hans-Ulrich Ulmer

  312. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

    Christi J van Asperen

  313. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

    Ans M W van den Ouweland & Juul T Wijnen

  314. Department of Epidemiology, Unit of Hereditary Cancer, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

    Liliana Varesco

  315. Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany

    Raymonda Varon-Mateeva

  316. Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde SERGAS, Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain

    Ana Vega

  317. Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela, Santiago de Compostela, Spain

    Ana Vega

  318. Unit of Functional Onco-genomics and Genetics, CRO Aviano, National Cancer Institute, Aviano, Italy

    Alessandra Viel

  319. Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK

    Lisa Walker

  320. Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

    Zhaoming Wang

  321. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA

    Clarice R Weinberg

  322. Department of Biomedical Data Sciences, Stanford University School of Medicine, Stanford, California, USA

    Alice S Whittemore

  323. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

    Walter Willett

  324. Department of Medicine, Institute for Human Genetics, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA

    Elad Ziv

  325. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal

    Manuel R Teixeira

  326. Department of Obstetrics and Gynaecology, University of Melbourne and the Royal Women's Hospital, Melbourne, Victoria, Australia

    Jennifer Stone

  327. Clinical Genetics Research Laboratory, Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Kenneth Offit

  328. Department of Medicine, Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Kenneth Offit

  329. Department of Molecular Medicine, University La Sapienza, Rome, Italy

    Laura Ottini

  330. Department of Oncology, South General Hospital, Stockholm, Sweden

    Per Hall

  331. Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany

    Alfons Meindl

  332. Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Marjanka K Schmidt

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