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SWI/SNF complex in cancer

Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.

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Figure 1: New remodeling mechanisms underline the tumor-suppressive function of the SWI/SNF complex.

References

  1. Stern, M., Jensen, R. & Herskowitz, I. J. Mol. Biol. 178, 853–868 (1984).

    Article  CAS  Google Scholar 

  2. Neigeborn, L. & Carlson, M. Genetics 108, 845–858 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Kwon, H., Imbalzano, A.N., Khavari, P.A., Kingston, R.E. & Green, M.R. Nature 370, 477–481 (1994).

    Article  CAS  Google Scholar 

  4. Kadoch, C. et al. Nat. Genet. 45, 592–601 (2013).

    Article  CAS  Google Scholar 

  5. Wang, X. et al. Nat. Genet. 49, 289–295 (2017).

    Article  CAS  Google Scholar 

  6. Mathur, R. et al. Nat. Genet. 49, 296–302 (2017).

    Article  CAS  Google Scholar 

  7. Stanton, B.Z. et al. Nat. Genet. 49, 282–288 (2017).

    Article  CAS  Google Scholar 

  8. Kadoch, C. et al. Nat. Genet. 49, 213–222 (2017).

    Article  CAS  Google Scholar 

  9. Helming, K.C. et al. Nat. Med. 20, 251–254 (2014).

    Article  CAS  Google Scholar 

  10. Wang, X. et al. Cancer Res. 69, 8094–8101 (2009).

    Article  CAS  Google Scholar 

  11. Tamkun, J.W. et al. Cell 68, 561–572 (1992).

    Article  CAS  Google Scholar 

  12. Wilson, B.G. et al. Cancer Cell 18, 316–328 (2010).

    Article  CAS  Google Scholar 

  13. Bitler, B.G. et al. Nat. Med. 21, 231–238 (2015).

    Article  CAS  Google Scholar 

  14. Comet, I., Riising, E.M., Leblanc, B. & Helin, K. Nat. Rev. Cancer 16, 803–810 (2016).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Chao Lu or C David Allis.

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Lu, C., Allis, C. SWI/SNF complex in cancer. Nat Genet 49, 178–179 (2017). https://doi.org/10.1038/ng.3779

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