Supplementary Figure 3: Multiple-sequence alignment of vertebrate SMCHD1 orthologs and yeast Hsp90. | Nature Genetics

Supplementary Figure 3: Multiple-sequence alignment of vertebrate SMCHD1 orthologs and yeast Hsp90.

From: De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

Supplementary Figure 3

Residues mutated in BAMS are indicated by pink arrows. Residues mutated in FSHD are indicated by purple arrows. The conserved GHKL-ATPase motifs I–IV are shaded in blue. Hs, Homo sapiens; Mm, Mus musculus; Bt, Bos taurus; Gg, Gallus gallus; Md, Monodelphis domestica; Cm, Chelonia mydas; Xt, Xenopus tropicalis; Dr, Danio rerio; Sc, Saccharomyces cerevisiae. FSHD mutation reference: LOVD SMCHD1 variant database (see URLs).

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