Supplementary Figure 5 : The genetic association signals for Crohn’s disease prognosis and susceptibility at the MHC region are distinct.

From: Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

Supplementary Figure 5

(a) Manhattan plots for 22,125 MHC SNPs that were common to this analysis of Crohn’s disease prognosis (top; blue) and a large recent meta-analysis of Crohn’s disease susceptibility (5,956 cases, 14,927 controls5; bottom; red). (b) Scatterplot directly comparing the association P values between Crohn’s disease susceptibility and prognosis at these 22,125 common SNPs. Dotted lines indicate the significance threshold for suggestive association (P < 1 × 10–5). No SNPs that showed suggestive association in one analysis (of susceptibility or prognosis) were also suggestively associated in the other.