Supplementary Figure 2 : Fine-mapping at the FOXO3 locus.

From: Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

Supplementary Figure 2

Prognosis GWAS results (combined cohorts) at the FOXO3 locus; adapted from the LocusTrack plot1. Top, SNPs in the region with their –log10 (P value) plotted against genomic position and colored according to LD with the lead SNP (rs147856773). Genes in the region are indicated. The expanded plot includes SNPs, genes, and ChIP–seq data from the ENCODE Project2. H3K4me1 and H3K27ac data from CD14+ monocytes and p300 binding data from myeloid K562 cells are shown (no monocyte data were available). The transcription factor binding track displays regions of transcription factor binding identified in a large collection of ChIP–seq experiments performed by the ENCODE Project (further details available at http://genome.ucsc.edu/cgi-bin/hgTrackUi?g=wgEncodeRegTfbsClusteredV3#TRACK_HTML).